Anatomical Variation of Human Collector Channel Orifices.
Anatomical Variation of Human Collector Channel Orifices.
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DOI：
10.1167/iovs.15-17753
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发表时间：
2016-03
影响因子：
4.4
通讯作者：
Fautsch MP
中科院分区：
文献类型：
--
作者：
Bentley MD;Hann CR;Fautsch MP
检查正常人体集气管孔口的解剖变化及其与施累姆氏管的关系。将通过浸没或灌注固定的十个人体前节进行放射状解剖，并进一步通过精细解剖分为相应的内壁节段和外壁节段。将组织脱水、临界点干燥、溅射涂层，并通过扫描电子显微镜检查。图像的放大倍数为×200 至×10,000。选定的径向收集器通道区域经过塑料嵌入处理。确定了两类收集器通道孔口。简单的椭圆形孔口（直径 54.7 ± 4.6 µm）内衬有内皮细胞，最常出现在施累姆氏管外壁的平面区域。复杂的孔口（直径62.7±3.4μm）经常被发现与间隔柱和桥相关，并且通常覆盖有瓣状结构（10-40μm），这些结构在内壁和外壁之间以及收集器通道孔口上方延伸。简单孔口和复杂孔口均具有完整或部分唇状边缘。在具有部分边缘的孔口中，在与唇缘相对的外壁表面上经常可以看到槽状凹槽。横断的隔膜和内壁和外壁粘附部位经常被发现与复杂的收集器通道孔相关。收集器通道孔口结构多种多样，从简单的椭圆形到复杂的系留瓣和桥。具有复杂瓣片的收集器通道孔连接施累姆氏管的内壁和外壁，并且可以用于增强和调节这些区域的房水流出。
To examine the anatomical variation of normal human collector channel orifices and their relationship with Schlemm's canal. Ten human anterior segments fixed by immersion or perfusion were dissected radially and further divided by fine dissection into corresponding inner and outer wall segments. The tissues were dehydrated, critical-point dried, sputter coated, and examined by scanning electron microscopy. Images were obtained at magnifications from ×200 to ×10,000. Selected radial collector channel regions were processed for plastic embedding. Two classes of collector channel orifices were identified. Simple oval orifices (54.7 ± 4.6–μm diameter) were lined with endothelial cells and most often occurred on a planar region of Schlemm's canal outer wall. Complex orifices (62.7 ± 3.4–μm diameter) were often found associated with septal columns and bridges, and typically covered with flap-like structures (10–40 μm) that extended between the inner and outer wall and over the collector channel orifices. Both simple and complex orifices had complete or partial lip-like rims. In orifices with partial rims, a trough-like groove was often visible on the outer wall surface opposite the lip. Transected septa and inner and outer wall adhesion sites were often found in association with complex collector channel orifices. Collector channel orifice structure varied from simple ovals to complex tethered flaps and bridges. Collector channel orifices with complex flaps connect the inner and outer walls of Schlemm's canal, and may serve to enhance and regulate aqueous outflow in these regions.