Gentamicin and vancomycin do not impair experimental fracture healing
Gentamicin and vancomycin do not impair experimental fracture healing
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DOI：
10.1097/01.blo.0000144477.43661.59
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发表时间：
2004-10-01
影响因子：
4.2
通讯作者：
Patel, R
中科院分区：
文献类型：
--
作者：
Haleem, AA;Rouse, MS;Patel, R
本研究的目的是确定庆大霉素或万古霉素是否损害大鼠实验性骨折愈合。将41只雄性Wistar大鼠分为3组，分别接受1.5 mg/kg庆大霉素肌内注射，每日2次，持续3周（n = 15），25 mg/kg万古霉素腹腔注射，每日2次，持续3周（n = 14），或不治疗（n = 12），从7天后开始生产的闭合，非移位，双侧股骨骨折。庆大霉素和万古霉素的平均30分钟血清浓度分别为4.5 mug/mL和35.1 mug/mL。生物力学和影像学研究用于评估骨折愈合。暴露于庆大霉素和万古霉素的骨折骨痂的抗扭强度试验（分别为437和424 N-mm）与对照组（334 N-mm）相似。X线片显示，对照组动物（Goldberg评分，2.3）与庆大霉素和万古霉素治疗组大鼠（两组Goldberg评分，2.6）的愈合情况相似。本研究的结果未显示暴露于庆大霉素或万古霉素后实验性骨折愈合受损（如暴露于喹诺酮类药物后报告的情况）。
The purpose of this study was to determine whether gentamicin or vancomycin impair experimental fracture healing in rats. Forty-one male Wistar rats were divided into three groups, receiving either 1.5 mg/kg of gentamicin intramuscularly twice daily for 3 weeks (n = 15), 25 mg/kg of vancomycin intraperitoneally twice daily for 3 weeks (n = 14), or no treatment (n = 12), starting 7 days after production of closed, nondisplaced, bilateral femoral fractures. The mean 30 minute serum concentrations of gentamicin and vancomycin were 4.5 mug/mL and 35.1 mug/mL, respectively. Biomechanical and radiographic studies were used to evaluate fracture healing. Torsional strength testing of fracture callus exposed to gentamicin and vancomycin was similar (437 and 424 N-mm, respectively) to controls (334 N-mm). Radiographs showed similar healing in control animals (Goldberg score, 2.3) compared with rats treated with gentamicin and vancomycin (Goldberg score, 2.6 in both groups). Results of this study do not show impaired healing of experimental fractures after exposure to gentamicin or vancomycin (such as has been reported after exposure to quinolones).