Distributions of serum thyroid-stimulating hormone in 2020 thyroid disease-free adults from areas with different iodine levels: a cross-sectional survey in China
Distributions of serum thyroid-stimulating hormone in 2020 thyroid disease-free adults from areas with different iodine levels: a cross-sectional survey in China
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2020年不同碘水平地区无甲状腺疾病成人血清促甲状腺激素分布：中国横断面调查
DOI：
10.1007/s40618-020-01395-2
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发表时间：
2020-08-20
影响因子：
5.4
通讯作者：
Shen, H.
中科院分区：
文献类型：
--
作者：
Ren, B.;Wan, S.;Shen, H.
目的探讨我国不同碘水平地区无甲状腺疾病成人血清促甲状腺激素（TSH）水平的分布。方法2016年4月至2019年6月，对2020名健康成年人的血清TSH水平进行分析。结果高碘区（IFA）、适碘区（IAA）、高碘区（IEA）TSH中位数分别为2.32、2.11、2.34mIU/L，高碘区（IAA）TSH中位数分别为2.32、2.11、2.34mIU/L，高碘区（IEA）TSH中位数分别为2.32、2.11、2.34mIU/L。IFA和IEA组血清TSH浓度显著高于IAA组（p = 0.005和<0.0001）。多数成人TSH值分布在1.01-3.00mIU/L之间，三组间趋势一致。在我们的研究中，TSH水平不随年龄变化，女性的TSH水平高于男性（p <0.0001）。IAA（r =-0.160，p =0.0001）和IEA（r =-0.177，p =0.0001）中FT4与TSH呈负相关，IFA中FT4与TSH无相关性（r =-0.046，p =0.370）。BMI、吸烟状况、教育水平和婚姻状况与TSH相关。结论本研究为建立不同碘水平地区TSH参考区间提供了依据。
PurposeThe aim of the present study was to describe the distributions of serum thyroid- stimulating hormone (TSH) levels in thyroid disease-free adults from areas with different iodine levels in China. Meanwhile, we aimed to evaluate the influence of age and gender on the distribution of TSH, assess the relationship between concentrations of TSH and free thyroxine (FT4), and analyze the factors that may affect TSH levels.Methods2020 adults were included from April 2016 to June 2019. Urinary iodine concentration, serum iodine concentration, serum TSH, FT4, free triiodothyronine, thyroid peroxidase antibodies and thyroglobulin antibodies were measured, and thyroid ultrasonography was performed.ResultsThe median of TSH in iodine-fortification areas (IFA), iodine-adequate areas (IAA), iodine-excessive areas (IEA) were 2.32, 2.11 and 2.34 mIU/L, respectively. Serum TSH concentrations were significantly higher in IFA and IEA than that in IAA (p= 0.005 and < 0.0001). The TSH values of most adults were distributed within the range of 1.01–3.00 mIU/L with the same trend in three groups. In our study, TSH levels did not change with age, and the TSH level of females was higher than that of males (p< 0.0001). There was a negative correlation between FT4and TSH in IAA (r= − 0.160,p< 0.0001) and IEA (r= − 0.177,p< 0.0001), but there was no correlation between FT4and TSH in IFA (r= − 0.046,p= 0.370). BMI, smoking status, education levels, and marital status were associated with TSH.ConclusionOur study provides a basis for establishing the reference intervals of TSH in different iodine level areas.