PET imaging of ischemic neuronal death in the hippocampus of living monkeys
PET imaging of ischemic neuronal death in the hippocampus of living monkeys
复制标题
活体猴子海马缺血性神经元死亡的 PET 成像
DOI：
10.1002/hipo.1106
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发表时间：
2002
期刊：
影响因子：
3.5
通讯作者：
H. Tsukada
中科院分区：
文献类型：
--
作者：
Liang Zhao;T. Yamashima;Xiang;A. Tonchev;J. Yamashita;T. Kakiuchi;S. Nishiyama;S. Kuhara;Kazuhiro Takahashi;H. Tsukada
The aim of the present study was to visualize postischemic hippocampal neuronal death in the living monkey brain, using a high‐resolution positron emission tomography (PET) and novel radioligands. In preceding papers, we reported on postischemic hippocampal neuronal death in a model of Japanese monkeys (Macaca fuscata) undergoing a 20‐min complete whole‐brain ischemia. Using the same model here, we investigated the in vivo bindings of two radiotracers, [11C]Ro15‐4513 (a type II benzodiazepine receptor ligand) and [11C](+)3‐MPB (a muscarinic cholinergic receptor ligand), in the hippocampus on day 7 after ischemia, as compared to the normal hippocampus. A significant decrease in the in vivo binding of [11C]Ro15‐4513 and [11C](+)3‐MPB was observed in the postischemic monkey hippocampus on day 7 after ischemia compared to controls. Light and electron microscopic analyses of postischemic CA1 neurons showed typical features of coagulation necrosis, as associated with a marked reduction of postsynaptic densities and presynaptic vesicles. These results suggest that semiquantification of hippocampal neuronal death is possible in the living primate brain using PET, and that the same procedures can be applied for evaluating neuronal cell loss in patients with ischemic injuries and/or dementia. Hippocampus 2002;12:109–118. © 2002 Wiley‐Liss, Inc.
DOI：
10.1056/nejm198910123211506
发表时间：
1989
期刊：
The New England journal of medicine
影响因子：
--
作者：
Goyal,RK
通讯作者：
Goyal,RK
毒蕈碱乙酰胆碱受体拮抗剂 [11C]N-甲基哌啶基苯甲酸 ([11C]NMPB) 的合成、体内生物分布和剂量测定。
影响因子：
3.1
作者：
Mulholland,GK;Kilbourn,MR;Sherman,P;Carey,JE;Frey,KA;Koeppe,RA;Kuhl,DE
通讯作者：
Kuhl,DE