Comprehensive Behavioral Analysis of Male Ox1r (-/-) Mice Showed Implication of Orexin Receptor-1 in Mood, Anxiety, and Social Behavior.
Comprehensive Behavioral Analysis of Male Ox1r (-/-) Mice Showed Implication of Orexin Receptor-1 in Mood, Anxiety, and Social Behavior.
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DOI：
10.3389/fnbeh.2015.00324
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发表时间：
2015
影响因子：
3
通讯作者：
Sakurai T
中科院分区：
文献类型：
--
作者：
Abbas MG;Shoji H;Soya S;Hondo M;Miyakawa T;Sakurai T
神经肽食欲素A和食欲素B仅由下丘脑外侧区的神经元产生，在调节广泛的行为和稳态过程中起重要作用，包括调节睡眠/觉醒状态和能量稳态。食欲素系统与调节自主神经系统、情感、情绪、奖励系统和睡眠/觉醒状态的系统具有密切的解剖学和功能关系。最近使用选择性拮抗剂的药理学研究表明，食欲素受体-1（OX 1 R）参与调节情绪、奖赏系统和自主神经系统的生理过程。在这里，我们用全面的行为测试组合检查了Ox 1 r −/−小鼠，以筛选额外的OX 1 R功能。Ox 1 r −/−小鼠表现出焦虑样行为增加，抑郁样行为改变，自发运动活动轻微减少，社会互动减少，惊吓反应增加，前脉冲抑制减少。这些结果表明，OX 1 R除了在情绪和焦虑中发挥作用外，还在社会行为和感觉运动门控中发挥作用。
Neuropeptides orexin A and orexin B, which are exclusively produced by neurons in the lateral hypothalamic area, play an important role in the regulation of a wide range of behaviors and homeostatic processes, including regulation of sleep/wakefulness states and energy homeostasis. The orexin system has close anatomical and functional relationships with systems that regulate the autonomic nervous system, emotion, mood, the reward system, and sleep/wakefulness states. Recent pharmacological studies using selective antagonists have suggested that orexin receptor-1 (OX1R) is involved in physiological processes that regulate emotion, the reward system, and autonomic nervous system. Here, we examined Ox1r−/− mice with a comprehensive behavioral test battery to screen additional OX1R functions. Ox1r−/− mice showed increased anxiety-like behavior, altered depression-like behavior, slightly decreased spontaneous locomotor activity, reduced social interaction, increased startle response, and decreased prepulse inhibition. These results suggest that OX1R plays roles in social behavior and sensory motor gating in addition to roles in mood and anxiety.