Determination of MIC Distribution and Epidemiological Cutoff Values for Bedaquiline and Delamanid in Mycobacterium tuberculosis Using the MGIT 960 System Equipped with TB eXiST
Determination of MIC Distribution and Epidemiological Cutoff Values for Bedaquiline and Delamanid in Mycobacterium tuberculosis Using the MGIT 960 System Equipped with TB eXiST
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DOI：
10.1128/aac.00614-15
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发表时间：
2015-07-01
影响因子：
4.9
通讯作者：
Boettger, Erik C.
中科院分区：
文献类型：
--
作者：
Keller, Peter M.;Hoemke, Rico;Boettger, Erik C.
贝达喹啉（Sirturo）和delamanid（Deltyba）最近已被监管机构批准用于治疗耐多药结核病（MDR-TB）。尚未建立两种物质的抗菌药物敏感性试验。在使用配备EpiCenter/TB eXiST的MGIT 960系统的基础上，我们确定了野生型菌株的平均贝达喹啉MIC为0.65 mg/L（中位数，0.4毫克/升）和流行病学截止值（ECOFF）为1.6毫克/升;对于德拉马尼，测定的平均野生型药物MIC为0.013 mg/L（中位数，0.01 mg/L），ECOFF为0.04 mg/L。
Bedaquiline (Sirturo) and delamanid (Deltyba) have recently been approved by the regulatory authorities for treatment of multi-drug-resistant tuberculosis (MDR-TB). Antimicrobial susceptibility testing is not established for either substance. On the basis of the use of the MGIT 960 system equipped with EpiCenter/TB eXiST, we determined a mean bedaquiline MIC for wild-type strains of 0.65 mg/liter (median, 0.4 mg/liter) and an epidemiological cutoff (ECOFF) of 1.6 mg/liter; for delamanid, a mean wild-type drug MIC of 0.013 mg/liter (median, 0.01 mg/liter) and an ECOFF of 0.04 mg/liter were determined.