The infant rat as a model of bacterial meningitis.
The infant rat as a model of bacterial meningitis.
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作为细菌性脑膜炎模型的幼鼠。
DOI：
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发表时间：
1977
影响因子：
6.4
通讯作者：
J. Robbins
中科院分区：
文献类型：
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作者：
E. Moxon;M. Glodé;A. Sutton;J. Robbins
在幼年大鼠中研究了细菌性脑膜炎的发病机制。鼻内接种超过 10(3) 个 b 型流感嗜血杆菌会导致菌血症的发生率，该菌血症的发生率与攻击接种物的大小直接相关。菌血症与脑膜炎的时间和数量关系表明，细菌通过血行途径传播到脑膜，菌血症的程度是脑膜炎发展的主要决定因素。在一系列独立的实验中，喂食大肠杆菌菌株 C94 (O7:K1:H-) 的幼鼠出现定植并出现菌血症和脑膜炎，但当喂食大肠杆菌菌株 Easter (O75:K100:H5) 时，侵袭性疾病很少见。鼻内与口服攻击的比较表明，鼻咽是诱导流感嗜血杆菌菌血症的最有效途径，而胃肠途径是大肠杆菌 K1 血清型更有效的攻击途径。
The pathogenesis of bacterial meningitis was studied in infant rats. Intranasal intoculation of greater than 10(3) Haemophilus influenzae type b resulted in an incidence of bacteremia that was directly related to the size of hte challenge inoculum. The temporal and quantitative relationship of bacteremia to meningitis indicated that bacteria spread to the meninges by the hematogenous route and that the magnitude of bacteremia was a primary determinant in the development of meningitis. In a sparate series of experiments, infant rats that were fed Escherichia coli strain C94 (O7:K1:H-) became colonized and developed bacteremia and meningitis, but invasive disease was rare when rats were fed E. Coli strain Easter (O75:K100:H5). A comparison of intranasal vs. oral challenge indicated that the nasopharynx was the most effective route for inducing H. influenzae bacteremia, whereas the gastrointestinal route was the more effective challenge route for the E. coli K1 serotype.