Longitudinal Analysis of MRI T2 Knee Cartilage Laminar Organization in a Subset of Patients From the Osteoarthritis Initiative: A Texture Approach
Longitudinal Analysis of MRI T2 Knee Cartilage Laminar Organization in a Subset of Patients From the Osteoarthritis Initiative: A Texture Approach
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DOI：
10.1002/mrm.22693
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发表时间：
2011-04-01
影响因子：
3.3
通讯作者：
Majumdar, Sharmila
中科院分区：
文献类型：
--
作者：
Carballido-Gamio, Julio;Joseph, Gabby B.;Majumdar, Sharmila
软骨磁共振成像T-2松弛时间对水合作用、胶原含量和组织各向异性敏感，是膝骨性关节炎潜在的基于成像的生物标志物。这项纵向的初步研究提出了一种改进的软骨扁平化技术，该技术便于使用与软骨层平行和垂直的灰度共生矩阵进行纹理分析，并将该技术应用于13名骨性关节炎患者的膝关节软骨，这些受试者在基线、1年随访和2年随访中。软骨展平显示，在未展平和展平的T-2图之间，平均T-2值的失真最小(类似于0.5ms)。平坦化T-2图的灰度共生矩阵纹理分析发现，在基线、1年随访和2年随访时，垂直于和平行于软骨层的质地参数之间存在显著差异(P<；0.05)。趋势表现为与软骨层垂直的对比度、相异度、角度二阶矩和能量较高；与它们平行的较高的均质性、熵、方差和相关性。还发现了明显的(P<；0.05)纵向纹理变化，反映了椎板破裂的细微迹象。趋势表现为对比度、相异度和信息量减少；而同质性、能量和相关性增加。这项研究的结果需要进一步的调查，以完成对所提出的方法在膝骨性关节炎研究中的有效性的评估。Magn Reson Med 65：1184-1194,2011。(C)2010年Wiley-Liss公司
Cartilage magnetic resonance imaging T-2 relaxation time is sensitive to hydration, collagen content, and tissue anisotropy, and a potential imaging-based biomarker for knee osteoarthritis. This longitudinal pilot study presents an improved cartilage flattening technique that facilitates texture analysis using gray-level co-occurrence matrices parallel and perpendicular to the cartilage layers, and the application of this technique to the knee cartilage of 13 subjects of the osteoarthritis initiative at baseline, 1-year follow-up, and 2-year follow-up. Cartilage flattening showed minimum distortion (similar to 0.5 ms) of mean T-2 values between nonflattened and flattened T-2 maps. Gray-level co-occurrence matrices texture analysis of flattened T-2 maps detected a cartilage laminar organization at baseline, 1-year follow-up, and 2-year follow-up by yielding significant (P < 0.05) differences between texture parameters perpendicular and parallel to the cartilage layers. Tendencies showed higher contrast, dissimilarity, angular second moment, and energy perpendicular to the cartilage layers; and higher homogeneity, entropy, variance, and correlation parallel to them. Significant (P < 0.05) longitudinal texture changes were also detected reflecting subtle signs of a laminar disruption. Tendencies showed decreasing contrast, dissimilarity, and entropy; and increasing homogeneity, energy, and correlation. Results of this study warrant further investigation to complete the assessment of the usefulness of the presented methodology in the study of knee osteoarthritis. Magn Reson Med 65:1184-1194, 2011. (C) 2010 Wiley-Liss, Inc.