Hippocampal region-specific contributions to memory performance in normal elderly
Hippocampal region-specific contributions to memory performance in normal elderly
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DOI：
10.1016/j.bandc.2009.11.007
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发表时间：
2010-04-01
影响因子：
2.5
通讯作者：
Chee, Michael W. L.
中科院分区：
文献类型：
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作者：
Chen, Karren H. M.;Chuah, Lisa Y. M.;Chee, Michael W. L.
为了探讨健康老年人海马区体积与记忆的关系，对147名55~83岁的社区志愿者进行了磁共振成像、Groton迷宫学习测验、视觉再现和Rey听觉言语学习测验的评估。采用交互式体积测量法测定大鼠海马区体积。我们发现，与年龄相关的海马头体积相对于海马尾的体积减少得更多。在Groton迷宫学习测验中，右侧海马体体积与空间记忆相关，而左侧海马体体积与言语记忆延迟相关。这些关联与年龄、性别、教育程度和处理速度无关，并支持沿着海马体长轴进行功能分化的概念。(C)2009 Elsevier Inc.保留所有权利。
To investigate the relationship between regional hippocampal volume and memory in healthy elderly, 147 community-based volunteers, aged 55-83 years, were evaluated using magnetic resonance imaging, the Groton Maze Learning Test, Visual Reproduction and the Rey Auditory Verbal Learning Test. Hippocampal volumes were determined by interactive volumetry. We found greater age-related reduction in the volume of the hippocampal head relative to the tail. Right hippocampal tail volume correlated with spatial memory on the Groton Maze Learning Test while left hippocampal body volume was associated with delayed verbal memory. These associations were independent of age, sex, education and speed of processing and support the notion of functional differentiation along the long axis of the hippocampus. (C) 2009 Elsevier Inc. All rights reserved.