ASSESSMENT OF A FLUOROQUINOLONE, 3 BETA-LACTAMS, 2 AMINOGLYCOSIDES, AND A CYCLINE IN TREATMENT OF MURINE YERSINIA-PESTIS INFECTION
ASSESSMENT OF A FLUOROQUINOLONE, 3 BETA-LACTAMS, 2 AMINOGLYCOSIDES, AND A CYCLINE IN TREATMENT OF MURINE YERSINIA-PESTIS INFECTION
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DOI：
10.1128/aac.38.3.481
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发表时间：
1994-03-01
影响因子：
4.9
通讯作者：
CARNIEL, E
中科院分区：
文献类型：
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作者：
BONACORSI, SP;SCAVIZZI, MR;CARNIEL, E
阿莫西林、头孢噻肟、头孢曲松、庆大霉素、多西环素和氧氟沙星与参比药物链霉素一样，在体外对鼠疫耶尔森氏菌6/69 M强毒株具有活性。在标准化和可重复的全身感染小鼠模型中评价了这些药物在体内的比较效力。每种抗生素在感染后24 h静脉注射一次，然后在48 h内重复注射。通过计数从在选定时间处死的小鼠的整个脾脏中回收的活细菌来测量体内结果。所有的药物都是明显成功的;头孢曲松、氧氟沙星和参比药物是最有效的。因此，庆大霉素和强力霉素可根据Y的临床形式使用。鼠疫感染对β-内酰胺类抗生素，特别是本研究中使用的β-内酰胺类抗生素，可以进行进一步的研究，以确认或不确认它们对Y。鼠疫氧氟沙星在治疗小鼠Y染色体上的活性和作用与链霉素一样快。鼠疫感染，这与先前获得的成功一致，即使用氟喹诺酮治疗由其它致病性耶尔森氏菌引起的鼠感染。
Amoxicillin, cefotaxime, ceftriaxone, gentamicin, doxycycline, and ofloxacin were active in vitro, like the reference drug streptomycin, against the virulent strain Yersinia pestis 6/69M. The comparative efficacies of these drugs in vivo were evaluated in a standardized and reproducible mouse model of systemic infection. Each antibiotic was injected intravenously once, at 24 h postinfection, and then repeatedly during 48 h. In vivo results were measured by counting the viable bacteria recovered from the whole spleens of mice sacrificed at selected times. All the drugs were manifestly successful; ceftriaxone, ofloxacine, and the reference drug were the most effective. Therefore, gentamicin and doxycycline could be used, depending on the clinical forms of the Y. pestis infection. Further investigations on beta-lactams, especially those used in the present study, could be carried out to confirm or not confirm their activities against Y. pestis. Ofloxacin appeared to be as active and to perform as rapidly as streptomycin in the treatment of murine Y. pestis infection, which is in agreement with the previous successes obtained,vith the use of fluoroquinolones in the treatment of murine infections caused by other pathogenic yersiniae.