Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent -: A randomized controlled trial
Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent -: A randomized controlled trial
复制标题
作为一种潜在的抗肥胖剂的藤黄属植物（羟基柠檬酸）--： 随机对照试验
DOI：
10.1001/jama.280.18.1596
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发表时间：
1998-11-11
影响因子：
120.7
通讯作者：
Nunez, C
中科院分区：
文献类型：
--
作者：
Heymsfield, SB;Allison, DB;Nunez, C
上下文。-羟基柠檬酸是中药复方藤黄果中的活性成分，竞争性地抑制线粒体外酶三磷酸腺苷-柠檬酸（pro-3S）裂解酶。作为一种可能在抑制新生脂肪生成中起重要作用的柠檬酸裂解酶，黄果甙被认为可以降低人体体重和减少脂肪量。目的：评价藤黄果甙对超重者减重和减脂的功效。- 12周随机、双盲、安慰剂对照试验。-门诊体重控制研究单位。参与者。-超重男性和女性受试者（平均体重指数[体重（公斤）除以身高（米）的平方]，约为32 kg/m(2)）。受试者随机接受活性草药化合物（每天1500毫克羟基柠檬酸）或安慰剂，两组均采用高纤维、低能量饮食。治疗期12周。每隔一周评估体重，并在第0周和第12周测量脂肪量。主要结果测量。-体重变化和脂肪量变化。-共有135名受试者被随机分配到活性羟基柠檬酸组（n = 66）或安慰剂组（n = 69）；活性羟基柠檬酸组42例（64%）和安慰剂组42例（61%）完成了12周的治疗（P = 0.74）。两组患者在12周治疗期间体重均显著减轻（P < 0.001）；然而，组间体重减轻差异无统计学意义（mean [SD], 3.2 [3.3] kg vs 4.1 [3.9] kg; P = .14）。在治疗组之间，估计体脂质量减少的百分比没有显著差异，受试者体重减少的脂肪比例不受治疗组的影响。-与安慰剂相比，藤黄果未能显著减轻体重和减少脂肪量。
Context.-Hydroxycitric acid, the active ingredient in the herbal compound Garcinia cambogia, competitively inhibits the extramitochondrial enzyme adenosine triphosphate-citrate (pro-3S)-lyase. As a citrate cleavage enzyme that may play an essential role in de novo lipogenesis inhibition, G cambogia is claimed to lower body weight and reduce fat mass in humans.Objective.-To evaluate the efficacy of G cambogia for body weight and fat mass loss in overweight human subjects.Design.-Twelve-week randomized, double-blind, placebo-controlled trial.Setting.-Outpatient weight control research unit.Participants.-Overweight men and women subjects (mean body mass index [weight in kilograms divided by the square of height in meters], approximately 32 kg/m(2)).Intervention.-Subjects were randomized to receive either active herbal compound (1500 mg of hydroxycitric acid per day) or placebo, and both groups were prescribed a high-fiber, low-energy diet. The treatment period was 12 weeks. Body weight was evaluated every other week and fat mass was measured at weeks 0 and 12.Main Outcome Measures.-Body weight change and fat mass change.Results.-A total of 135 subjects were randomized to either active hydroxycitric acid (n = 66) or placebo (n = 69); 42 (64%) in the active hydroxycitric acid group and 42 (61%) in the placebo group completed 12 weeks of treatment (P = .74). Patients in both groups lost a significant amount of weight during the 12-week treatment period (P < .001); however, between-group weight loss differences were not statistically significant (mean [SD], 3.2 [3.3] kg vs 4.1 [3.9] kg; P = .14). There were no significant differences in estimated percentage of body fat mass loss between treatment groups, and the fraction of subject weight loss as fat was not influenced by treatment group.Conclusions.-Garcinia cambogia failed to produce significant weight loss and fat mass loss beyond that observed with placebo.