Characterization of the Continuous Elastic Parameters of Porcine Vocal Folds
Characterization of the Continuous Elastic Parameters of Porcine Vocal Folds
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DOI：
10.1016/j.jvoice.2018.09.007
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发表时间：
2020-01-01
期刊：
影响因子：
2.2
通讯作者：
Leonessa, Alexander
中科院分区：
文献类型：
--
作者：
Burks, Garret;De Vita, Raffaella;Leonessa, Alexander
本文通过单轴拉伸试验对猪声带的弹性特性进行了评价。下声带组织样本在纵向上受到张力，同时采用数字图像相关技术来确定整个测试过程中的应变值。应力-应变结果显示出一个低应变线性区，其次是一个非线性指数，然后是一个较高的应变线性区。按照与先前研究[1]中提出的类似优化方法分析了来自16个猪声带样本的数据，以产生描述组织弹性特性的连续模型参数。发现平均低应变线性模量值和高应变线性模量值分别为17.86 kPa和609.27 kPa。该模型还确定了两个过渡点的位置：p（1），描述了在0.122 +/-0.058 mm/mm处从低应变线性区域到指数区域的转变，以及p（2），描述了在0.308 +/-0.069 mm/s处从指数到高应变线性区域的转变。发现平均数据集的指数区域由关系式sigma（m）（σ（xx））= 0.083e（19.32 σ xx）+ 2.0951 kPa描述。除了定位过渡点外，优化方法在所有应变值上保持模量连续性。将0至0.40 mm/mm应变范围内的平均弹性模量值与分别在0.05和0.35 mm/mm下测量的代表性低应变和高应变线性模量进行比较。两个过渡点和线性模量值之间的所有应变间隔之间存在统计学显着差异。这些结果表明，需要考虑过渡点的位置，并进一步突出的非线性和弹性模量的变化，这是特别重要的，当使用切除的猪声带作为模型发声。结果量化连续的线性和非线性参数描述的弹性特性，可用作未来切除喉测试的框架，同时评估声音产生的动力学，这在很大程度上依赖于组织的弹性特性。
This paper presents an evaluation of the elastic properties of porcine vocal folds through uniaxial tensile tests. Inferior vocal fold tissue samples were subjected to tension in the longitudinal direction while digital image correlation techniques were employed to determine strain values throughout the tests. The stress-strain results showed a low-strain linear region, followed by both a nonlinear exponential and then a higher strain linear region. Data from 16 porcine vocal fold samples were analyzed following a similar optimization method as proposed in prior studies [1] to yield continuous model parameters which describe the elastic properties of the tissue. The average low and high strain linear modulus values were found to be 17.86 kPa and 609.27 kPa, respectively. The model also identified the location of two transition points: p(1), describing the transition from the low-strain linear region to an exponential region at 0.122 +/- 0.058 mm/mm and p(2), describing the transition from the exponential to the high strain linear region at 0.308 +/- 0.069 mm/mm. The exponential region of the averaged data set was found to be described by the relationship sigma(m)(epsilon(xx)) = 0.083e(19.32 epsilon xx) + 2.0951 kPa. In addition to locating transition points, the optimization method maintained modulus continuity across all strain values. Averaged elastic modulus values across strain from 0 to 0.40 mm/mm were compared to representative low and high strain linear modulus which were measured at 0.05 and 0.35 mm/mm, respectively. Statistically significant differences were found among all strain intervals between the two transition points and the linear modulus values. These results indicate the need to consider the location of transition points and further highlight the nonlinearity and changes in elastic modulus which are especially important when using excised porcine vocal folds as a model for phonation. The results quantify continuous linear and nonlinear parameters describing the elastic properties which can be used as a framework for future excised larynx tests and while evaluating the dynamics of sound production, which rely heavily on the elastic properties of the tissue.