Body Mass Index May Modify Asthma Prevalence Among Low-Birth-Weight Children
Body Mass Index May Modify Asthma Prevalence Among Low-Birth-Weight Children
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DOI：
10.1093/aje/kwr484
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发表时间：
2012-07-01
影响因子：
5
通讯作者：
Lin, Ruey-Shiung
中科院分区：
文献类型：
--
作者：
Lu, Frank Leigh;Hsieh, Chia-Jung;Lin, Ruey-Shiung
儿童哮喘是一个日益严重的健康问题，与低出生体重和高体重指数有关。这项研究验证了一个假设，即有低出生体重史的超重和肥胖青少年患哮喘的风险更大。1995年至1996年间，台湾共有75,871名初中生接受哮喘筛检。出生体重和估计胎龄从出生登记处获得。对混杂变量进行逻辑回归和简单回归分析校正。哮喘在出生体重低于3000克和青少年体重指数较高的人群中更为普遍。此外，具有这两种特征的人最容易患哮喘。无论低出生体重者的哮喘诊断是由医生指定还是由医学问卷指定，超重（医生诊断：优势比= 1.41；医学问卷：优势比= 1.25）和肥胖（医生诊断：优势比= 1.38；医学问卷：优势比= 1.47）男孩以及超重（医生诊断：优势比= 1.63；医学问卷：优势比= 1.30）和肥胖(医生诊断：优势比= 1.44；医学问卷：优势比= 1.32)女生（P < 0.05）。出生时体重过低的人容易患哮喘，而体重过重则会增加患哮喘的风险。性别差异被观察到。本研究提示产前护理和营养咨询可以降低哮喘患病率。
Childhood asthma, a growing health concern, has been associated with low birth weight and elevated body mass index. This study tested the hypothesis that overweight and obese adolescents with a history of low birth weight are at even greater risk of developing asthma. A cohort of 75,871 junior high school students was screened for asthma during 1995-1996 in Taiwan. Birth weight and estimated gestational age were obtained from the birth registry. Logistic regression and simple regression analyses were adjusted for confounding variables. Asthma was more prevalent in those with birth weights below 3,000 g and higher adolescent body mass indexes. Furthermore, those with both characteristics were consistently most likely to have asthma. Whether the asthma diagnosis among low-birth-weight subjects was assigned by physicians or medical questionnaire, the risks were elevated for both overweight (physician diagnosis: odds ratio = 1.41; medical questionnaire: odds ratio = 1.25) and obese (physician diagnosis: odds ratio = 1.38; medical questionnaire: odds ratio = 1.47) boys as well as overweight (physician diagnosis: odds ratio = 1.63; medical questionnaire: odds ratio = 1.30) and obese (physician diagnosis: odds ratio = 1.44; medical questionnaire: odds ratio = 1.32) girls (P < 0.05). Low birth weight predisposes one to develop asthma, and excess body mass amplifies the risk. A sex difference was observed. This study suggests that prenatal care and nutritional counseling could reduce asthma prevalence.