Fas receptor up-regulation and membrane localization concurrent with apoptosis in idiopathic esophageal ulceration: toward a better understanding of esophageal injury in AIDS.
Fas receptor up-regulation and membrane localization concurrent with apoptosis in idiopathic esophageal ulceration: toward a better understanding of esophageal injury in AIDS.
复制标题
特发性食管溃疡中 Fas 受体上调和膜定位与细胞凋亡同时发生：更好地了解 AIDS 中的食管损伤。
DOI：
10.1086/314832
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Kim,KH
中科院分区：
文献类型：
--
作者：
Houghton,J;Korah,RM;Kim,KH
Activation of the Fas-mediated apoptotic pathway in the etiology of idiopathic esophageal ulcerations (IEUs) was investigated. Constitutive expression of Fas ligand (Fas L) was found in the basal layer of the normal esophageal mucosa and in IEUs and cytomegalovirus ulcerations. In addition to an altered cytokine environment, there was significant up-regulation of Fas antigen mRNA and membrane localization of the receptor in IEU specimens. Concomitant increase in the basic components of Fas machinery, together with elevated mucosal apoptosis, strongly suggests the potential role of the Fas signaling pathway in the onset of tissue destruction associated with IEUs.
