Supramolecular block copolymer for gene delivery: Enhancement of transfection efficacy by charge regulation
Supramolecular block copolymer for gene delivery: Enhancement of transfection efficacy by charge regulation
复制标题
用于基因传递的超分子嵌段共聚物：通过电荷调节增强转染效率
作者：
Wumaier Yasen;Ruijiao Dong;Linzhu Zhou;Yu Huang;Dongbo Guo;Dong Chen;Chuanlong Li;Aliya Aini;Xinyuan Zhu
一类电荷易于控制的阳离子超分子嵌段共聚物已被开发出来。经合成后结构优化，该共聚物表现出相当的生物相容性，大大提高了pDNA缩合能力和生物稳定性，并进一步提高了体外转染效率。这项工作提供了有价值的见解先进的非病毒载体的基因传递的创造。
A class of cationic supramolecular block copolymers with readily controlled charges has been exploited. Upon post-synthetic structural optimization, this copolymer exhibits comparable biocompatibility, greatly improved pDNA condensation capability and biostability, and further enhanced transfection efficiency in vitro. This work provides valuable insight into the creation of advanced nonviral vectors for gene delivery.