Five-point Likert scaling on MRI predicts clinically significant prostate carcinoma
Five-point Likert scaling on MRI predicts clinically significant prostate carcinoma
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DOI：
10.1186/s12894-015-0087-5
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发表时间：
2015-09-04
期刊：
影响因子：
2
通讯作者：
Shinohara, Nobuo
中科院分区：
文献类型：
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作者：
Harada, Taisuke;Abe, Takashige;Shinohara, Nobuo
背景：旨在阐明使用 5 点 Likert 系统衡量的前列腺癌概率与相应肿瘤灶的生物学特征之间的关系。方法：本研究涉及 44 名患者，他们在腹腔镜根治性前列腺切除术前接受 3.0-Tesla 多参数 MRI。根据病理和 MRI 结果进行追踪。使用5点李克特系统评估癌症概率与相应肿瘤灶的生物学特征之间的关系。结果：从44个标本中总共鉴定出102个肿瘤灶。在 102 个肿瘤中，55 个肿瘤根据 MRI 结果进行评分（评分 1：n = 3；评分 2：n = 3；评分 3：n = 16；评分 4：n = 11；评分 5：n = 22），而 47 个肿瘤未在 MRI 上指出。追踪研究显示，>0.5 cm(3)肿瘤的比例随着Likert评分的升级而增加（1或2分：33%；3分：68.8%；4或5分：90.9%，chi(2)检验，p < 0.0001）。格里森评分 >7 的比例也从量表 2 增加到量表 5（量表 2：0 %；量表 3：56.3 %；量表 4：72.7 %；5：90.9 %，chi(2) 检验，p = 0.0001）。以3分或更高分数作为MRI癌症检出阈值时，如果肿瘤体积超过0.5 cm(3)，则检出率显着提高（< 0.2 cm(3)：10.3 %；0.2-0.5 cm(3)：25 %；0.5-1.0 cm(3)：66.7 %；1.0 < cm(3)：92.1 %).结论：每个李克特量表都很好地反映了 相应的肿瘤体积和格里森评分。我们的观察表明，在考虑治疗方案时，“3 分或更高”可能是预测临床显着癌症的有用阈值。
Background: To clarify the relationship between the probability of prostate cancer scaled using a 5-point Likert system and the biological characteristics of corresponding tumor foci.Methods: The present study involved 44 patients undergoing 3.0-Tesla multiparametric MRI before laparoscopic radical prostatectomy. Tracing based on pathological and MRI findings was performed. The relationship between the probability of cancer scaled using the 5-point Likert system and the biological characteristics of corresponding tumor foci was evaluated.Results: A total of 102 tumor foci were identified histologically from the 44 specimens. Of the 102 tumors, 55 were assigned a score based on MRI findings (score 1: n = 3; score 2: n = 3; score 3: n = 16; score 4: n = 11 score 5: n = 22), while 47 were not pointed out on MRI. The tracing study revealed that the proportion of >0.5 cm(3) tumors increased according to the upgrade of Likert scores (score 1 or 2: 33 %; score 3: 68.8 %; score 4 or 5: 90.9 %,chi(2) test, p < 0.0001). The proportion with a Gleason score >7 also increased from scale 2 to scale 5 (scale 2: 0 %; scale 3: 56.3 %; scale 4: 72.7 %; 5: 90.9 %, chi(2) test, p = 0.0001). On using score 3 or higher as the threshold of cancer detection on MRI, the detection rate markedly improved if the tumor volume exceeded 0.5 cm(3) (< 0.2 cm(3): 10.3 %; 0.2-0.5 cm(3): 25 %; 0.5-1.0 cm(3): 66.7 %; 1.0 < cm(3): 92.1 %).Conclusions: Each Likert scale favobably reflected the corresponding tumor's volume and Gleason score. Our observations show that "score 3 or higher" could be a useful threshold to predict clinically significant carcinoma when considering treatment options.