Serial measurements of higher-order aberrations after blinking in patients with dry eye
Serial measurements of higher-order aberrations after blinking in patients with dry eye
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DOI：
10.1167/iovs.07-0762
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发表时间：
2008-01-01
影响因子：
4.4
通讯作者：
Tano, Yasuo
中科院分区：
文献类型：
--
作者：
Koh, Shizuka;Maeda, Naoyuki;Tano, Yasuo
目的。目的研究干眼症患者眨眼后高阶像差(HOAs)的动态变化。方法应用波前传感器对20例(20只眼)干眼症患者的HOAs进行30s连续测量。20只眼分为两组，有或无中央角膜浅层点状角膜病变(SPK)。在测量过程中，受试者被要求每10秒眨眼一次。分析了中心直径为4 mm的类彗星、类球体和六阶Zernike多项式的像差数据。比较两组间总HOA及随时间变化的波动指数(FI)和稳定性指数(SI)。结果：有中央性黄斑裂孔的干眼的总黄斑面积显著大于无中央性黄斑裂孔的干眼(P=0.001)。在有中心性SPK的干眼中，总HOA的顺序模式具有较高的初始值和持续较高的值，而在无中央性SPK的干眼中，总HOA持续较低，与正常眼的模式相似。结论干眼的HOA增加至少部分是由于光学区以上的SPK引起的。干眼的低泪量可能不会导致眨眼后HOA的连续增加。连续测量HOA可能有助于评估干眼患者光学质量的连续变化。
PURPOSE. To study the sequential postblink changes in ocular higher-order aberrations (HOAs) in patients with dry eye.METHODS. A wavefront sensor was used to measure HOAs sequentially for 30 seconds in 20 eyes of 20 patients with dry eye. The 20 eyes were classified into two groups, with or without superficial punctate keratopathy (SPK) in the central cornea. During the measurement, subjects were required to blink every 10 seconds. The aberration data were analyzed in the central 4-mm diameter for coma-like, spherical-like, and total HOAs up to sixth-order Zernike polynomials. Total HOAs, as well as fluctuation index (FI) and stability index (SI) of the total HOAs over time were compared between the two groups. The sequential changes in coma-like aberration, spherical-like aberration, and total HOAs were also investigated.RESULTS. The total ocular HOAs were significantly (P = 0.001) greater in dry eyes with central SPK than in dry eyes without central SPK. The sequential pattern of the total ocular HOAs had higher initial and consistently higher values in dry eyes with central SPK, whereas that of dry eyes without central SPK showed consistently lower total HOAs that were similar to the pattern of normal eyes.CONCLUSIONS. Increased HOAs in dry eye at least partially result from SPK above the optical zone. The low tear volume in dry eye may not cause sequential increases in HOAs after blinking. Sequential measurement of HOAs may be useful for evaluating the sequential changes in optical quality in patients with dry eye.