Predatory stem cells in the non-zebrafish chordate, Botryllus schlosseri.
Predatory stem cells in the non-zebrafish chordate, Botryllus schlosseri.
复制标题
非斑马鱼脊索动物 Botryllus schlosseri 中的捕食性干细胞。
DOI：
10.1089/zeb.2005.1.357
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发表时间：
2005
期刊：
影响因子：
2
通讯作者：
DeTomaso,AnthonyW
中科院分区：
文献类型：
--
作者：
Laird,DianaJ;DeTomaso,AnthonyW
SchlosseriBotryllus是一种原始的海洋脊索动物，它为干细胞生物学研究提供了一种新的模式生物。首先是B。灰葡萄孢是一种群体性生物，经历连续而有规律的无性发育。2灰葡萄孢成虫每周进行自我再生，包括所有的体细胞组织和生殖细胞。其次，在自然条件下，负责细胞可以在两个个体之间移动和移植。一旦移植，这些细胞可以增殖，分化，并经常完全取代生殖系和/或体细胞组织中的宿主细胞。这些过程分别被称为生殖细胞寄生（gcp）或体细胞寄生（scp），我们已经证明在这个过程中有赢家和输家，这意味着干细胞的竞争能力是由基因决定的。干细胞生物学的基本特征，如自我更新能力，归巢，或分化动力学，必须强调一种基因型的干细胞竞争另一种基因型的干细胞的能力，我们正在使用这个系统前瞻性地分离细胞负责和分析gcp和scp表型的分子机制。
Botryllus schlosseriis a primitive marine chordate which provides a new model organism to study stem cell biology for several reasons. First,B. schlosseriis a colonial organism that undergoes continuous and regular asexual development.Botryllusadults regenerate themselves, including all somatic tissues and the germline, every week. Second, under natural conditions the cells responsible can mobilize and transplant between two individuals. Once transplanted, these cells can proliferate, differentiate, and often completely replace the cells of the host in both the germline and/or somatic tissues. These processes are called germ cell parasitism (gcp), or somatic cell parasitism (scp), respectively, and we have shown that there are winners and losers in this process, implying that the competitive ability of stem cells is a genetically-determined trait. Fundamental characteristics of stem cell biology, such as self-renewal capacity, homing, or differentiation kinetics must underlie the ability of a stem cell of one genotype to out-compete a stem cell of another genotype, and we are using this system prospectively to isolate the cells responsible and to analyze the molecular mechanisms underlying gcp and scp phenotypes.