DEVELOPMENT OF LEUKEMIA IN MICE TRANSGENIC FOR THE TAX GENE OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I
DEVELOPMENT OF LEUKEMIA IN MICE TRANSGENIC FOR THE TAX GENE OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I
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DOI：
10.1073/pnas.92.4.1057
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发表时间：
1995-02-14
影响因子：
11.1
通讯作者：
RATNER, L
中科院分区：
文献类型：
--
作者：
GROSSMAN, WJ;KIMATA, JT;RATNER, L
人类 T 细胞白血病病毒 I 型 Tax 蛋白反式激活与 T 细胞复制和激活有关的多个细胞基因。为了研究其致白血病的潜力，Tax 通过使用人颗粒酶 B 启动子靶向转基因小鼠的成熟 T 淋巴细胞区室。这些小鼠发展为大颗粒淋巴细胞白血病，表明淋巴细胞区室中Tax的表达足以导致白血病的发展。此外，这些观察结果表明，人类T细胞白血病病毒感染可能与大颗粒淋巴细胞白血病的发展有关。
The human T-cell leukemia virus type I Tax protein trans-activates several cellular genes implicated in T-cell replication and activation. To investigate its leukemogenic potential, Tax was targeted to the mature T-lymphocyte compartment in transgenic mice by using the human granzyme B promoter. These mice developed large granular lymphocytic leukemia, demonstrating that expression of Tax in the lymphocyte compartment is sufficient for the development of leukemia. Furthermore, these observations suggest that human T-cell leukemia virus infection may be involved in the development of large granular lymphocytic leukemia.