Rational construction of AIEgens with wide color tunability and their specific lipid droplet imaging applications.
Rational construction of AIEgens with wide color tunability and their specific lipid droplet imaging applications.
复制标题
DOI：
10.1039/d0tb01806f
复制
发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Fei Zhang;Zhe Li;Yaoming Liu;Binsheng Yang;H. Qiao;Jie Chai;Guangming Wen;B. Liu
中科院分区：
文献类型：
--
作者：
Fei Zhang;Zhe Li;Yaoming Liu;Binsheng Yang;H. Qiao;Jie Chai;Guangming Wen;B. Liu
具有聚集诱导发光（AIE）特性的有机发光材料在成像、可视化和传感等领域得到了迅速发展。本文通过在聚集致猝灭（ACQ）化合物上安装转子，构建了一个AIE发光团（AIEgens）系统（A2-A4，B1-B3），该系统具有宽的发射调谐范围，几乎覆盖了可见光的所有波段（400-780 nm）。计算得到的化合物的能隙与吸收跃迁值一致。在生物学实验中，B3在PC 12细胞中表现出良好的脂滴（LD）靶向能力，并且与商业LD生物探针相比具有更高的光稳定性。此外，作为疏水化合物，B3可以区分高脂血症患者和正常人的血液。本研究为构建具有AIE特性的红色/近红外荧光材料，并将其应用于高脂血症患者血液的检测提供了一种思路。
Organic light-emitting materials with aggregation-induced emission (AIE) character have experienced a rapid development in imaging, visualization and sensing. In this paper, by installing rotors to an aggregation-caused quenching (ACQ) compound, we constructed an AIE luminogen (AIEgens) system (A2-A4, B1-B3) with wide emission tunability, which covers almost all regions of visible light (400-780 nm). The calculated energy gap of the compounds is consistent with the value of the absorption transition. In the biological experiments, B3 showed excellent lipid droplet (LD) targeting ability in PC12 cells, and higher photostability compared with the commercial LDs bioprobe. Moreover, as a hydrophobic compound, B3 can distinguish blood from a hyperlipidemia patient and normal people. Thus, this study provides a strategy to construct red/NIR fluorescent materials with AIE character, and further apply it to identify the blood of people with hyperlipidemia.