Endoscopic Ultrasound Elastography for Differential Diagnosis of Pancreatic Masses: A Meta-Analysis
Endoscopic Ultrasound Elastography for Differential Diagnosis of Pancreatic Masses: A Meta-Analysis
复制标题
内镜超声弹性成像对胰腺肿块鉴别诊断的荟萃分析
DOI：
10.1007/s10620-012-2428-5
复制
发表时间：
2013-04-01
影响因子：
3.1
通讯作者：
Zhu, Qi
中科院分区：
文献类型：
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作者：
Hu, Duan-min;Gong, Ting-ting;Zhu, Qi
背景：目前的影像学技术对胰腺肿瘤的良恶性鉴别仍具有挑战性.内镜超声（EUS）弹性成像进一步提高了EUS表征胰腺insulines.AimsTo评估，结合现有试验的数据，EUS弹性成像诊断恶性肿瘤的胰腺masses.MethodsAll相关研究发表的数据库系统检索确定的准确性。使用随机效应模型进行荟萃分析，结合联合收割机研究results.ResultsSeven研究涉及752例患者。EUS弹性成像对胰腺实性肿块鉴别诊断的敏感性为97%（95%CI，0.95-0.98），特异性为76%（95%CI，0.69-0.82）。受试者工作特征曲线（SROC）下的面积为0.9529。联合阳性似然比为3.71（95%CI，2.72-5.07），阴性似然比为0.05（95%CI，0.02-0.13）。结论我们的荟萃分析表明，EUS弹性成像是一个有用的工具，用于鉴别诊断胰腺实性肿瘤具有非常高的敏感性和相对较低的特异性。结果表明，EUS弹性成像不仅提供了与EUS互补的信息，而且还可能增加细针抽吸的产量，减少不必要的活检次数。
BackgroundDistinguishing malignant from benign pancreatic tumors is challenging with current imaging techniques. Endoscopic ultrasound (EUS) elastography has further improved the efficacy of EUS for characterizing pancreatic lesions.AimsTo assess, by combining data from existing trials, the accuracy of EUS elastography in diagnosing malignant tumors for patients with pancreatic masses.MethodsAll relevant studies published were identified by systematic searching of databases. A meta-analysis was performed using a random-effects model to combine study results.ResultsSeven studies involving 752 patients were included. The sensitivity of EUS elastography for differential diagnosis of solid pancreatic masses was 97 % (95 % CI, 0.95–0.98), and the specificity was 76 % (95 % CI, 0.69–0.82). The area under the curve under summary receiver operating characteristic (SROC) was 0.9529. The combined positive likelihood ratio was 3.71 (95 % CI, 2.72–5.07), and the negative likelihood ratio was 0.05 (95 % CI, 0.02–0.13).ConclusionOur meta-analysis shows that EUS elastography is a useful tool for differential diagnosis of solid pancreatic neoplasms with very high sensitivity and relatively low specificity. The results indicate that EUS elastography not only provides information complementary to that from EUS but also potentially increases the yield of fine needle aspiration and reduces the number of unnecessary biopsies.