The Fra-1: Novel role in regulating extensive immune cell states and affecting inflammatory diseases.
The Fra-1: Novel role in regulating extensive immune cell states and affecting inflammatory diseases.
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Fra-1：在调节广泛免疫细胞状态和影响炎症性疾病方面的新作用
DOI：
10.3389/fimmu.2022.954744
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发表时间：
2022
影响因子：
7.3
通讯作者：
Wu, Qing-Ping
中科院分区：
文献类型：
--
作者：
He, Yu-Yao;Zhou, Hai-Feng;Chen, Lu;Wang, Yan-Ting;Xie, Wan-Li;Xu, Zhen-Zhen;Xiong, Yue;Feng, Yi-Qi;Liu, Guo-Yang;Li, Xia;Liu, Jie;Wu, Qing-Ping
Fos相关抗原1（Fra-1，Fos-related antigen 1）是转录因子激活蛋白（AP-1）的一个成员，在细胞增殖、凋亡、分化、炎症、肿瘤发生和肿瘤转移中起重要作用。越来越多的证据表明，直接靶向Fra-1可以显著改变肿瘤的恶性程度和侵袭能力。此外，Fra-1的作用在免疫和炎症环境中逐渐显现，如关节炎、肺炎、银屑病和心血管疾病。这些协调免疫和非免疫细胞的调节机制是Fra-1作为多种人类疾病的潜在治疗靶点的基础。本文就Fra-1在免疫系统中的作用作一综述，着重介绍Fra-1在调节组织稳态中的重要作用。此外，我们还讨论了疾病中可能的关键干预策略，这也概述了未来的研究和发展途径。
Fra-1(Fos-related antigen1), a member of transcription factor activator protein (AP-1), plays an important role in cell proliferation, apoptosis, differentiation, inflammation, oncogenesis and tumor metastasis. Accumulating evidence suggest that the malignancy and invasive ability of tumors can be significantly changed by directly targeting Fra-1. Besides, the effects of Fra-1 are gradually revealed in immune and inflammatory settings, such as arthritis, pneumonia, psoriasis and cardiovascular disease. These regulatory mechanisms that orchestrate immune and non-immune cells underlie Fra-1 as a potential therapeutic target for a variety of human diseases. In this review, we focus on the current knowledge of Fra-1 in immune system, highlighting its unique importance in regulating tissue homeostasis. In addition, we also discuss the possible critical intervention strategy in diseases, which also outline future research and development avenues.
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
30.5
作者：
Chang, Jae-Hoon;Xiao, Yichuan;Hu, Hongbo;Jin, Jin;Yu, Jiayi;Zhou, Xiaofei;Wu, Xuefeng;Johnson, Howard M.;Akira, Shizuo;Pasparakis, Manolis;Cheng, Xuhong;Sun, Shao-Cong
通讯作者：
Sun, Shao-Cong
影响因子：
8
作者：
Belguise, K;Kersual, N;Chalbos, D
通讯作者：
Chalbos, D
影响因子：
8
作者：
Belguise, K.;Milord, S.;Chalbos, D.
通讯作者：
Chalbos, D.
影响因子：
17.1
作者：
Beaulieu, Marie-Eve;Jauset, Toni;Soucek, Laura
通讯作者：
Soucek, Laura