Irradiation of choroidal melanoma with iodine 125 ophthalmic plaque.
Irradiation of choroidal melanoma with iodine 125 ophthalmic plaque.
复制标题
用碘 125 眼科斑块照射脉络膜黑色素瘤。
DOI：
10.1001/archopht.1980.01020040305019
复制
发表时间：
1980
影响因子：
--
通讯作者：
B. Chan
中科院分区：
文献类型：
--
作者：
S. Packer;M. Rotman;R. Fairchild;D. Albert;H. Atkins;B. Chan
放射性碘125是一种具有物理特性的低能伽马同位素，适用于眼内肿瘤的照射。金属眼科敷贴器被设计成在允许照射肿瘤的同时保护重要的眼睛结构。我们比较了碘125和钴60的辐射效应。将绿色黑色素瘤移植到兔脉络膜上腔内。然后肿瘤生长为眼内肿块，接受放射治疗，并在摘除眼球前进行两个月的随访。组织病理学检查确定了碘125和钴60对肿瘤和其他眼结构的辐射损伤程度。用125碘照射的眼睛受到的辐射损伤很小，而肿瘤是无菌的。钴60照射的眼睛显示出实质性的辐射损伤，黑色素瘤没有得到完全的治疗。我们的结果支持使用碘125治疗眼内肿瘤。对于最佳的总剂量和剂量率，还需要更多的研究。
Radioactive iodine 125 is a low-energy gamma isotope with physical characteristics suitable for irradiation of intraocular tumors. Metal ophthalmic applicators have been designed to shield vital ocular structures while allowing irradiation of the tumor. We compared the radiation effects of iodine 125 and cobalt 60. The Greene melanoma was transplanted into the suprachoroidal space of rabbits. The tumor then grew as an intraocular mass, was irradiated, and was followed up for two months before enucleation. Histopathologic examination defined the extent of the radiation damage to the tumor and other ocular structures from the iodine 125 and from the cobalt 60. The eye irradiated with iodine 125 suffered minimal radiation damage, whereas the tumor was sterilized. The eye irradiated with cobalt 60 showed substantial radiation damage, and the melanoma was incompletely treated. Our results support the use of iodine 125 in treating intraocular tumors. More research is needed as to optimum total dose and dose rate.