Cognitive impairment has a strong relation to nonsomatic symptoms of depression in relapsing-remitting multiple sclerosis.
Cognitive impairment has a strong relation to nonsomatic symptoms of depression in relapsing-remitting multiple sclerosis.
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认知障碍与复发缓解型多发性硬化症抑郁症的非躯体症状密切相关。
DOI：
10.1093/arclin/acs113
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
T. Brismar
中科院分区：
文献类型：
--
作者：
M. Sundgren;L. Maurex;Å. Wahlin;F. Piehl;T. Brismar
目前尚不清楚多发性硬化症 (MS) 中的认知障碍如何受到身体残疾、疲劳和抑郁的影响。我们的目的是确定复发缓解型多发性硬化症 (RRMS) 患者认知障碍的最强临床预测因子。分析中包括的临床危险因素包括身体残疾（EDSS）、疲劳（FSS）、抑郁症的躯体和非躯体成分（BDI）、疾病进展率[多发性硬化症严重程度评分（MSSS）]和精神药物。认知障碍在患者中的患病率为 30.5%，优先影响注意力、执行功能、处理速度和视觉感知/组织。 MSSS 与认知障碍、抑郁或疲劳无关。在回归模型中，认知表现最好通过抑郁症的非躯体症状单独或与身体残疾相结合来预测。排除服用任何精神药物的患者并不影响结果。我们的结果强调了在怀疑 RRMS 患者认知障碍时评估抑郁症状的重要性。
It is unclear how cognitive impairment in multiple sclerosis (MS) is influenced by physical disability, fatigue, and depression. Our aim was to identify the strongest clinical predictors for cognitive impairment in relapsing-remitting MS (RRMS) patients. The clinical risk factors included in the analysis were physical disability (EDSS), fatigue (FSS), the somatic and nonsomatic components of depression (BDI), disease progression rate [Multiple Sclerosis Severity Score (MSSS)], and psychotropic medication. Cognitive impairment had a prevalence of 30.5% in patients affecting preferentially attention, executive functions, processing speed and visual perception/organization. MSSS was not associated with cognitive impairment, depression, or fatigue. In regression models, cognitive performance was best predicted by the nonsomatic symptoms of depression alone or in combination with physical disability. Exclusion of patients with any psychotropic medication did not influence the results. Our results underscore the importance of evaluating depressive symptoms when suspecting cognitive impairment in patients with RRMS.