Motor-skill learning: Changes in synaptic organization of the rat cerebellar cortex
Motor-skill learning: Changes in synaptic organization of the rat cerebellar cortex
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DOI：
10.1006/nlme.1996.0062
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发表时间：
1996-09-01
影响因子：
2.7
通讯作者：
Greenough, WT
中科院分区：
文献类型：
--
作者：
Anderson, BJ;Alcantara, AA;Greenough, WT
先前发现，在运动技能学习任务上训练30天的大鼠在与浦肯野细胞成比例的组织体积中具有比运动或不活动的大鼠更多的突触。在运动学习任务中，戴帽大鼠被要求穿越一个需要平衡和协调的障碍课程。两个运动组的大鼠被要求快速行走或允许在活动轮上跑步。对照在标准饲养中相对不活跃，每天处理一次。对突触进行分类，以确定哪些突触类型在旁正中小叶分子层的不同水平上发生了数量变化。运动学习组每单位浦肯野细胞参考体积中平行纤维突触和攀爬纤维突触明显多于其他组。在最外层的分子层中，每个参考体积中的突触和平行纤维突触也多于最内层。这里报道的可塑性发生在正常生理条件下的体内。兴奋性突触占分子层中突触的至少80%。结果支持先前的预测，平行纤维突触是可修改的学习条件。(C)出版社：Academic Press，Inc.
Rats trained on motor-skill learning tasks for 30 days were previously found to have more synapses in the volume of tissue proportional to a Purkinje cell than rats that exercised or were inactive. In the motor learning tasks, hooded rats were required to traverse an obstacle course requiring balance and coordination. Rats in two exercise groups were required to walk rapidly or allowed to run in activity wheels. Controls were relatively inactive in standard housing and handled once daily. Synapses were classified to determine which synaptic types changed in number across levels of the molecular layer in the paramedian lobule. The motor learning group had significantly more parallel fiber synapses and climbing fiber synapses per unit Purkinje cell reference volume than all other groups. There were also more synapses and more parallel fiber synapses per reference volume in the outermost than in the innermost molecular layer. The plasticity reported here occurs in vivo under normal physiological conditions. Excitatory synapses account for at least 80% of the synapses in the molecular layer. The results support prior predictions that parallel fiber synapses are modifiable during conditions of learning. (C) 1996 Academic Press, Inc.