Oral administration of putrescine inhibits Cryptosporidium parvum infection of neonatal C57BL-6 mice and is independent of nitric oxide synthesis
Oral administration of putrescine inhibits Cryptosporidium parvum infection of neonatal C57BL-6 mice and is independent of nitric oxide synthesis
复制标题
DOI：
10.2307/3284255
复制
发表时间：
1997-08-01
影响因子：
1.3
通讯作者：
Harp, JA
中科院分区：
文献类型：
--
作者：
Waters, WR;Reinhardt, TA;Harp, JA
我们研究了口服腐胺（精氨酸代谢的副产物）预防新生C57 BL-6小鼠隐孢子虫感染的有效性。在7日龄时用寄生虫攻击小鼠。与对照小鼠相比，从3至10日龄接受腐胺的小鼠具有延迟的感染模式。从3日龄到21日龄接受腐胺的小鼠没有被感染，而对照组小鼠被严重感染。我们还支持腐胺抑制C.通过增强一氧化氮（NO）的产生来抑制小鼠的细小病毒感染，肠胃外接受NO抑制剂N ω-L-精氨酸甲酯（L-NAME）和口服腐胺的小鼠没有被感染。因此，腐胺抑制C.以NO非依赖的方式感染细小病毒。
We examined the efficacy of oral administration of putrescine (a byproduct of arginine metabolism) in the prevention of Cryptosporidium parvum infection of neonatal C57BL-6 mice. Mice were challenged with the parasite at 7 days of age. Mice receiving putrescine from 3 through 10 days of age had a delayed pattern of infection as compared with control mice. Mice receiving putrescine from 3 through 21 days of age did not become infected, whereas control mice were heavily infected. We also rested the hypothesis that putrescine inhibited C. parvum infection by enhancing nitric oxide (NO) production, Mice receiving the NO inhibitor N omega-L-arginine methyl ester (L-NAME) parenterally and putrescine orally did not become infected. Thus, it appears that putrescine inhibits C. parvum infection in an NO-independent manner.