Primary cilia and dendritic spines: different but similar signaling compartments.
Primary cilia and dendritic spines: different but similar signaling compartments.
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初级纤毛和树突棘:不同但相似的信号传导室。
DOI:
10.1007/s10059-013-0246-z
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发表时间:
2013-10
影响因子:
3.8
通讯作者:
Sengupta, Piali
中科院分区:
文献类型:
--
作者:
Nechipurenko, Inna V.;Doroquez, David B.;Sengupta, Piali
Primary non-motile cilia and dendritic spines are cellular compartments that are specialized to sense and transduce environmental cues and presynaptic signals, respectively. Despite their unique cellular roles, both compartments exhibit remarkable parallels in the general principles, as well as molecular mechanisms, by which their protein composition, membrane domain architecture, cellular interactions, and structural and functional plasticity are regulated. We compare and contrast the pathways required for the generation and function of cilia and dendritic spines, and suggest that insights from the study of one may inform investigations into the other of these critically important signaling structures.
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