Primary cilia and dendritic spines: different but similar signaling compartments.

Primary cilia and dendritic spines: different but similar signaling compartments.
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初级纤毛和树突棘:不同但相似的信号传导室。

DOI:
10.1007/s10059-013-0246-z
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发表时间:
2013-10
影响因子:
3.8
通讯作者:
Sengupta, Piali
Sengupta, Piali
中科院分区:
生物学3区
文献类型:
--
作者:
Nechipurenko, Inna V.;Doroquez, David B.;Sengupta, Piali

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初级非运动纤毛和树突棘是细胞区室,分别专门用于感知和识别环境线索和突触前信号。尽管他们独特的细胞作用,这两个隔间表现出显着的平行的一般原则,以及分子机制,通过它们的蛋白质组成,膜结构域架构,细胞相互作用,结构和功能的可塑性进行调节。我们比较和对比纤毛和树突棘的生成和功能所需的途径,并建议从一个研究的见解可能会通知调查到其他这些至关重要的信号结构。
Primary non-motile cilia and dendritic spines are cellular compartments that are specialized to sense and transduce environmental cues and presynaptic signals, respectively. Despite their unique cellular roles, both compartments exhibit remarkable parallels in the general principles, as well as molecular mechanisms, by which their protein composition, membrane domain architecture, cellular interactions, and structural and functional plasticity are regulated. We compare and contrast the pathways required for the generation and function of cilia and dendritic spines, and suggest that insights from the study of one may inform investigations into the other of these critically important signaling structures.
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