Ovarian Epithelioid Trophoblastic Tumor in a Cynomolgus Monkey
Ovarian Epithelioid Trophoblastic Tumor in a Cynomolgus Monkey
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食蟹猴卵巢上皮样滋养细胞肿瘤
DOI：
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
M. Carcangiu
中科院分区：
文献类型：
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作者：
A. Giusti;A. Terrón;S. Belluco;E. Scanziani;M. Carcangiu
上皮样滋养细胞肿瘤（ETT）是一种罕见的滋养细胞肿瘤，其特征类似于癌。在这项研究中，我们描述了一个4岁的食蟹猴（Macaca fascicularis）显示，在尸检时，一个分叶状肿块取代左卵巢和几个结节性病变内的肺部。组织学上，卵巢和肺转移瘤中的肿块以上皮样细胞巢为特征，与合体滋养层细胞一致的混合、偶见、多核肿瘤细胞和中等数量的嗜酸性透明样物质。免疫组化结果显示，肿瘤细胞呈细胞角蛋白（AE 1/AE 3）和α-珠蛋白（α-珠蛋白）弥漫性阳性，而人绒毛膜促性腺激素仅呈局灶性免疫反应，而胎盘碱性磷酸酶始终呈阴性。根据形态学和免疫组化反应，肿瘤细胞被确定为中间滋养细胞。
Epithelioid trophoblastic tumor (ETT) is an unusual type of trophoblastic tumor, with features resembling carcinoma. In this study, we describe a 4-year-old cynomolgus monkey (Macaca fascicularis) showing, at necropsy, a lobulated mass replacing the left ovary and several nodular lesions within the lungs. Histologically, the mass in the ovary and lung metastases were characterized by nests of epithelioid cells, with intermingled, occasional, multinucleate tumor cells consistent with syncytiotrophoblasts and moderate amount of eosinophilic, hyaline-like material. Immunohistochemically, the tumor cells were diffusely positive for cytokeratins (AE1/AE3) and inhibin-α, but only focal immunoreactivity was observed for human chorionic gonadotropin, whereas placental alkaline phosphatase was always negative. On the basis of morphology and immunohistochemical reactivity, tumor cells were identified as intermediate trophoblast.
恒河猴的导管内乳腺癌和良性卵巢畸胎瘤。
影响因子：
0.7
作者：
Eydelloth,RS;Swindle,MM
通讯作者：
Swindle,MM
两只恒河猴（Macaca mulatta）的水脑畸形。
影响因子：
0.7
作者：
Binhazim,AA;Buchl,SJ
通讯作者：
Buchl,SJ