Homunculus
Homunculus
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侏儒
DOI：
10.1007/978-3-319-20791-9_479-1
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Murase Amadeo
中科院分区：
文献类型：
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作者：
Murase Amadeo
双膦酸盐相关性颌骨骨坏死（BRONJ）是一种药物不良反应，表现为骨破坏和/或死亡。纤维性发育不良（FD）是一种罕见的骨性疾病，其特征是异常的纤维骨组织，对感染的抵抗力降低。FD后BRONJ的有效治疗尚不清楚。在这里，我们报告，先进的BRONJ与FD成功地治疗了手术切除。一名69岁的女性，其左上颌骨显示磨玻璃外观的计算机断层扫描（CT）图像，正在服用阿仑膦酸钠。拔牙后1年，在拔牙部位观察到骨暴露，CT图像显示分离的死骨。在临床诊断为2期BRONJ并FD的情况下，我们不仅进行了死骨切除术，而且还进行了FD的部分切除术。此后，康复顺利，没有复发。总之，我们的病例表明，手术切除对FD相关的晚期BRONJ是有用的。
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is an adverse drug reaction represented by destruction and/or death of bone. Fibrous dysplasia (FD) is a rare bony disorder characterised by abnormal fibro-osseous tissue that has lowered resistance to infection. Effective treatments for BRONJ that follows FD are unclear. Here, we report that advanced BRONJ associated with FD was successfully treated by surgical resection. A 69-year-old woman, whose left maxillary bone showed a ground glass appearance on computed tomography (CT) images, was taking alendronate. At 1 year after teeth within the abnormal bone were extracted, exposed bone was observed in the extraction sites and CT images revealed separated sequestrums. Under the clinical diagnosis of Stage 2 BRONJ with FD, we performed not only sequestrectomy but also a partial resection of the FD. Thereafter, the healing was uneventful without recurrence. In conclusion, our case suggests that surgical resection is useful for advanced BRONJ associated with FD.