Inverse associations between androgens and renal function: the Young Men Cardiovascular Association (YMCA) study.
Inverse associations between androgens and renal function: the Young Men Cardiovascular Association (YMCA) study.
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雄激素与肾功能之间的负相关：青年男性心血管协会 (YMCA) 研究。
DOI：
10.1038/ajh.2008.307
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发表时间：
2009
影响因子：
3.2
通讯作者：
Zukowska-Szczechowska,Ewa
中科院分区：
文献类型：
--
作者：
Tomaszewski,Maciej;Charchar,FadiJ;Maric,Christine;Kuzniewicz,Roman;Gola,Mateusz;Grzeszczak,Wladyslaw;Samani,NileshJ;Zukowska-Szczechowska,Ewa
背景男性患非糖尿病肾病的风险高于女性。这种男性对肾病的易感性可能是由性激素等性别特异性因素介导的。方法我们对肾功能（根据 Cockcroft-Gault 方程估计的肌酐清除率）与循环性类固醇水平（总睾酮、总雌二醇、雌酮、雄烯二酮、硫酸脱氢表雄酮 (DHEA-S) 和二氢睾酮）之间的关联进行了横断面检查，928年轻（平均年龄：18.5 ± 1.2 岁）男性。 结果在对瘦男性（体重指数 (BMI) 低于中位数的男性）的粗略分析中，雄烯二酮和 DHEA-S 均与肾功能呈负线性相关。然而，在调整后，只有 DHEA-S 在瘦受试者中保留了其与肾功能的相关性——假设其他自变量 1 s.d 没有变化。 DHEA-S 的增加与 13%-s.d 相关。肌酐清除率降低（P=0.004）。仅在非瘦（BMI 大于中位数）受试者的粗略分析中，睾酮在肌酐清除率三分位数上有所下降（P < 0.001）。假设其他自变量没有变化的调整回归分析表明 1 s.d.总睾酮的增加与 11%-s.d 有关。非瘦男性的肌酐清除率降低（P=0.006）。因子分析证实肾功能与两种性类固醇呈负相关，并且在瘦身（DHEA-S）和非瘦身（睾酮）受试者中肾小球滤过相关因素的负载模式不同。结论我们的数据可能表明，在没有心血管疾病史的表面健康男性中，雄激素与估计的肾功能呈负相关。美国高血压杂志（2008）。 doi:10.1038/ajh.2008.307
BackgroundMen exhibit higher risk of nondiabetic renal diseases than women. This male susceptibility to renal disease may be mediated by gender-specific factors such as sex hormones.MethodsWe have undertaken a cross-sectional examination of associations between renal function (creatinine clearance estimated based on Cockcroft–Gault equation) and circulating levels of sex steroids (total testosterone, total estradiol, estrone, androstenedione, dehydroepiandrosterone sulfate (DHEA-S), and dihydrotestosterone) in 928 young (mean age: 18.5 ± 1.2 years) men.ResultsBoth androstenedione and DHEA-S showed inverse linear associations with renal function in the crude analysis of lean men (those with body mass index (BMI) less than median). However, only DHEA-S retained its association with renal function in lean subjects after adjustment—assuming no changes in other independent variables 1 s.d. increase in DHEA-S was associated with 13%-s.d. decrease in creatinine clearance (P= 0.004). Testosterone decreased across tertiles of creatinine clearance only in the crude analysis of nonlean (BMI greater than median) subjects (P< 0.001). The adjusted regression analysis that assumed no changes in other independent variables showed that 1 s.d. increase in total testosterone was associated with 11%-s.d. decrease in creatinine clearance of nonlean men (P= 0.006). Factor analysis confirmed an inverse association of renal function with both sex steroids and a different pattern of their loadings on glomerular filtration–related factors in lean (DHEA-S) and nonlean (testosterone) subjects.ConclusionsOur data may suggest that androgens are inversely associated with estimated renal function in apparently healthy men without history of cardiovascular disease.American Journal of Hypertension(2008). doi:10.1038/ajh.2008.307