Color and genomic ancestry in Brazilians: A study with forensic microsatellites
Color and genomic ancestry in Brazilians: A study with forensic microsatellites
复制标题
DOI：
10.1159/000096872
复制
发表时间：
2006-01-01
期刊：
影响因子：
1.8
通讯作者：
Pena, Sergio D. J.
中科院分区：
文献类型：
--
作者：
Pimenta, Juliana R.;Zuccherato, Luciana W.;Pena, Sergio D. J.
巴西的人口是由美洲印第安人、欧洲人和非洲人广泛混合而成的，是世界上变化最大的人口之一。我们最近发表了一项研究，使用祖先信息标记得出结论，在巴西，在个人水平上，颜色，由物理评估确定，是一个穷人的预测基因组祖先，估计分子标记。为了证实这些发现，我们进行了本调查的基础上的数据，从12个市售的法医微卫星被用来估计个人基因组起源的752个人从城市的圣保罗，属于不同的巴西颜色类别（275白色，192中间和285黑色）。基因型允许计算非洲或欧洲血统的个人似然比估计。虽然12个标记集证明能够区分欧洲和非洲的个人，我们观察到非常显着的重叠之间的三个颜色类别的巴西人。这是证实了定量使用贝叶斯分析的人口结构，并没有表现出显着的遗传分化之间的三个颜色组。这些结果证实和验证了我们以前的结论，使用祖先信息标记，在巴西在个人层面上有显着的分离的颜色和基因组血统。
The population of Brazil, formed by extensive admixture between Amerindians, Europeans and Africans, is one of the most variable in the world. We have recently published a study that used ancestry-informative markers to conclude that in Brazil, at an individual level, color, as determined by physical evaluation, was a poor predictor of genomic ancestry, estimated by molecular markers. To corroborate these findings we undertook the present investigation based on data from 12 commercially available forensic microsatellites that were utilized to estimate the personal genomic origin for each of 752 individuals from the city of Sao Paulo, belonging to different Brazilian color categories (275 Whites, 192 Intermediates and 285 Blacks). The genotypes permitted the calculation of a personal likelihood-ratio estimator of African or European ancestry. Although the 12 marker set proved capable of discriminating between European and African individuals, we observed very significant overlaps among the three color categories of Brazilians. This was confirmed quantitatively using a Bayesian analysis of population structure that did not demonstrate significant genetic differentiation between the three color groups. These results corroborate and validate our previous conclusions using ancestry-informative markers that in Brazil at the individual level there is significant dissociation of color and genomic ancestry.