Functional magnetic resonance imaging of macaque monkeys performing visually guided saccade tasks: Comparison of cortical eye fields with humans
Functional magnetic resonance imaging of macaque monkeys performing visually guided saccade tasks: Comparison of cortical eye fields with humans
复制标题
DOI：
10.1016/s0896-6273(04)00047-9
复制
发表时间：
2004-03-04
期刊：
影响因子：
16.2
通讯作者：
Miyashita, Y
中科院分区：
文献类型：
--
作者：
Koyama, M;Hasegawa, I;Miyashita, Y
额叶和顶叶眼区是灵长类大脑的功能标志，尽管它们在人类和猕猴之间的对应关系尚不清楚。我们在4.7 T下对执行视觉引导扫视任务的猴子进行了fMRI，并使用相同的范例将大脑激活与人类进行了比较。在多种顶叶激活中，猴的背外侧顶内区和人类的后上级顶叶小叶中的一个区域对扫视方向表现出最高的选择性。在额叶皮层，选择性是最高的交界处的中央前和上级额沟在人类和猴子的额叶眼场（FEF）。在猴子的运动前区（BA6）中也发现了BOLD激活峰，这表明假定的人FEF（BA6，通过成像研究提出）和猴子FEF（BA8，通过微刺激研究确定）之间的位置明显差异部分源于方法学差异。
The frontal and parietal eye fields serve as functional landmarks of the primate brain, although their correspondences between humans and macaque monkeys remain unclear. We conducted fMRI at 4.7 T in monkeys performing visually-guided saccade tasks and compared brain activations with those in humans using identical paradigms. Among multiple parietal activations, the dorsal lateral intraparietal area in monkeys and an area in the posterior superior parietal lobule in humans exhibited the highest selectivity to saccade directions. In the frontal cortex, the selectivity was highest at the junction of the precentral and superior frontal sulci in humans and in the frontal eye field (FEF) in monkeys. BOLD activation peaks were also found in premotor areas (BA6) in monkeys, which suggests that the apparent discrepancy in location between putative human FEF (BA6, suggested by imaging studies) and monkey FEF (BA8, identified by microstimulation studies) partly arose from methodological differences.