Cancer mortality in German male workers exposed to phenoxy herbicides and dioxins
Cancer mortality in German male workers exposed to phenoxy herbicides and dioxins
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DOI：
10.1007/bf00052936
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发表时间：
1996-05-01
影响因子：
2.3
通讯作者：
Wahrendorf, J
中科院分区：
文献类型：
--
作者：
Becher, H;FleschJanys, D;Wahrendorf, J
在一项职业队列研究中，对接触苯氧类除草剂和污染物（二恶英和呋喃）与癌症死亡率之间的关系进行了调查，共纳入德国四家工厂的2,479名工人，死亡率随访至1989年底（一个队列随访至1992年底），共记录了484例死亡，总死亡率的标准化死亡率（SMR）为101（95%置信区间[CI] = 92-111）。生产了各种除草剂，包括那些已知被2,3,7,8-四氯二苯并-对二恶英（TCDD）污染的除草剂，在四种植物中的两种植物中发生了高二恶英和呋喃暴露（特别是暴露于TCDD，但也暴露于高氯化二恶英），这是工人样本的血脂测量结果。所有肿瘤的死亡率都随着潜伏期的增加而增加，在TCDD血药浓度最高的最大植物中死亡率最高。在整个队列中，呼吸道癌（SMR = 154, CI = 115-202）、口腔和咽喉癌（SMR = 295, CI = 135-560）和非霍奇金淋巴瘤（SMR = 326, CI = 119-710）的死亡率都有所增加。我们的发现与其他队列的结果一致，这些结果表明长期暴露于这些苯氧类除草剂和二恶英后，总体癌症死亡率和呼吸道癌症死亡率增加。
In an occupational cohort study, the relation between exposure to phenoxy herbicides, and contaminants (dioxins and furans) and cancer mortality was investigated, A total of 2,479 workers from four plants in Germany were included, with a mortality follow-up until the end of 1989 (for one cohort, until the end of 1992), A total of 484 deaths were recorded yielding a standardized mortality ratio (SMR) of 101 (95 percent confidence interval [CI] = 92-111) for total mortality, and an SMR of 119 (CI = 100-141) for all malignant diseases, A variety of herbicides was produced, including those which are known to have been contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), High dioxin and furan exposure (in particular, exposure to TCDD, but also to higher chlorinated dioxins) had occurred in two of the four plants as shown by blood-fat measurements in a sample of workers, Mortality from all neoplasms increased with latency and was highest in the largest plant where the highest TCDD blood levels were recorded, An increased mortality in the total cohort from respiratory cancer (SMR = 154, CI = 115-202), cancer of the buccal cavity and pharynx (SMR = 295, CI = 135-560), and non-Hodgkin's lymphoma (SMR = 326, CI = 119-710) was observed, Our findings are consistent with results from other cohorts which showed an increased overall cancer mortality and mortality of respiratory cancer after long-term exposure to these phenoxy herbicides and dioxins.