The Tortoiseshell Pattern in One or Both Sides of the Submandibular Glands in Mucosa‐Associated Lymphoid Tissue Lymphoma Is Related to Chromosomal Aberrations and the Disease Extent
The Tortoiseshell Pattern in One or Both Sides of the Submandibular Glands in Mucosa‐Associated Lymphoid Tissue Lymphoma Is Related to Chromosomal Aberrations and the Disease Extent
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DOI：
10.7863/jum.2010.29.1.111
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发表时间：
2010-01
影响因子：
2.3
通讯作者：
S. Asai;K. Okami;N. Nakamura;Y. Ogawa;Y. Ohta;Yoko Ogase;Guilan Jin;H. Matsushita;H. Miyachi
中科院分区：
文献类型：
--
作者：
S. Asai;K. Okami;N. Nakamura;Y. Ogawa;Y. Ohta;Yoko Ogase;Guilan Jin;H. Matsushita;H. Miyachi
客观的。下颌下腺粘膜相关淋巴组织（MALT）淋巴瘤的病变是局部的或与染色体畸变相关的全身受累的一部分。本系列旨在探讨颌下腺MALT淋巴瘤的超声特征及其与染色体畸变和疾病范围的关系。方法。本系列研究共纳入 5 例下颌下腺不伴有干燥综合征的 MALT 淋巴瘤患者。在对主要病变进行手术活检之前，患者使用高分辨率换能器对下颌下腺进行超声检查。描述了病变的超声特征，包括其位置、后回声的存在、纹理和内部回声的存在。结果。所有病例的超声检查均显示低回声和实性肿块，后回声增强增强。低回声小隔室排列，由高回声轮廓线划分，具有龟甲图案。根据其位置分为左右两侧颌下腺病变和两侧颌下腺病变两种，分别见于3例和2例。后2例染色体畸变分别为t(11;18)(q23;q23)和t(12;18)(q22;q21)，并提示继发性器官受累。结论。颌下腺 MALT 淋巴瘤的超声表现以原发性和继发性病变中的龟甲图案为特征。在颌下腺两侧检测到这种模式可以作为染色体畸变和疾病系统性参与的指标。
Objective. Lesions of mucosa‐associated lymphoid tissue (MALT) lymphoma in the submandibular glands are localized or a part of systemic involvement in association with chromosomal aberrations. This series was undertaken to investigate the sonographic features of MALT lymphoma in the submandibular glands and their relationships with chromosomal aberrations and the disease extent. Methods. A total of 5 patients with MALT lymphoma without Sjögren syndrome in the submandibular glands were enrolled in this series. Patients underwent sonography of the submandibular glands with a high‐resolution transducer before surgical biopsy of the main lesion. Sonographic characteristics of the lesions were described for their location, presence of a posterior echo, texture, and presence of an internal echo. Results. Sonography in all cases showed hypoechoic and solid masses with increased posterior echo enhancement. There was an arrangement of hypoechoic small compartments demarcated by hyperechoic contour lines, which had a tortoiseshell pattern. This pattern was classified into 2 types according to its location: a lesion in the right or left side and lesions in both sides of the submandibular glands, found in 3 and 2 patients, respectively. The latter 2 cases had chromosomal aberrations of t(11;18)(q23;q23) and t(12;18)(q22;q21), respectively, and were revealed as secondary organ involvement. Conclusions. The sonographic appearance of MALT lymphoma in the submandibular glands was characterized by the tortoiseshell pattern in both primary and secondary lesions. Detection of this pattern in both sides of the submandibular glands can be an indicator of chromosomal aberrations and systematic involvement of the disease.