Tebuconazole derivatives are potent inhibitors of strigolactone biosynthesis
Tebuconazole derivatives are potent inhibitors of strigolactone biosynthesis
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DOI：
10.1584/jpestics.d13-011
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发表时间：
2013-01-01
影响因子：
2.4
通讯作者：
Asami, Tadao
中科院分区：
文献类型：
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作者：
Ito, Shinsaku;Umehara, Mikihisa;Asami, Tadao
为了寻找马立内酯(SL)生物合成抑制剂，我们筛选了能降低水稻中2‘-epi-5-deoxstrigol(epi-5ds)水平的含唑化合物。作为筛选的结果，戊唑醇是一种已知的针对麦角固醇生物合成的杀菌剂，被选为有效的SL生物合成抑制剂。为了寻找更有效的SL生物合成抑制剂，对戊唑醇进行了构效关系研究。通过对2-(2-chlorophenyl)-4-(4-chlorophenyl)-1-(1H-1，2，4-triazol-1-yl)丁烷-2-醇(4b)和4-(4-氯苯基)-2-(4-苯氧基苯基)-1(-1H-1，2，4-三唑-1-基)丁烷-2-醇(4e)对表观-5DS生物合成的抑制活性的评价，发现其具有较强的抑制表观-5DS生物合成的能力。(C)日本农药科学学会
To find strigolactone (SL) biosynthesis inhibitors, we screened the azole-containing chemicals that reduce the level of 2' -epi-5-deoxystrigol (epi-5DS) in rice. As a result of the screening, tebuconazole, a known fungicide targeting ergosterol biosynthesis, was selected as a potent SL biosynthesis inhibitor. A structure-activity relationship study of tebuconazole was carried out to discover more potent SL biosynthesis inhibitors. By evaluating the inhibitory activity on epi-5DS biosynthesis, we found that 2-(2-chlorophenyl)-4-(4-chlorophenyl)-1-(1H-1,2,4-triazol-1-yl) butan-2-ol (4b) and 4-(4-chlorophenyl)-2-(4-phenoxyphenyl) -1 (-1H-1,2,4-triazol-1-yl)butan-2-ol (4e) showed potent ability to reduce epi-5DS biosynthesis. (C) Pesticide Science Society of Japan