Micro- and nanodevices integrated with biomolecular probes.
Micro- and nanodevices integrated with biomolecular probes.
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DOI：
10.1016/j.biotechadv.2015.09.001
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发表时间：
2015-12
影响因子：
16
通讯作者：
Gurkan UA
中科院分区：
文献类型：
--
作者：
Alapan Y;Icoz K;Gurkan UA
了解生物分子、蛋白质和细胞如何与其周围环境和其他生物实体相互作用已成为大多数生物医学微纳设备的基本设计标准。生物、医学和纳米制造技术的进步相辅相成，使我们能够设计出基于生物分子作为探针的新工具。自然界中的工程化微纳米系统和生物分子在功能、大小和物理性质方面具有非常强大的兼容性。本文介绍了以生物分子探针作为其重要组成部分而设计和制造的微纳尺度器件的最新进展。介绍了一般的设计和制造概念，重点介绍了三种主要的平台技术：微悬臂梁、微纳米管和微流控技术。通过强调重大成就、当前挑战和未来机遇，介绍了每种技术的概述、典型的制造细节和应用领域。
Understanding how biomolecules, proteins and cells interact with their surroundings and other biological entities has become the fundamental design criterion for most biomedical micro- and nanodevices. Advances in biology, medicine, and nanofabrication technologies complement each other and allow us to engineer new tools based on biomolecules utilized as probes. Engineered micro/nanosystems and biomolecules in nature have remarkably robust compatibility in terms of function, size, and physical properties. This article presents the state of the art in micro- and nanoscale devices designed and fabricated with biomolecular probes as their vital constituents. General design and fabrication concepts are presented and three major platform technologies are highlighted: microcantilevers, micro/nanopillars, and microfluidics. Overview of each technology, typical fabrication details, and application areas are presented by emphasizing significant achievements, current challenges, and future opportunities.