Cigarette smoking and suicidal behaviour: results from a 25-year longitudinal study
Cigarette smoking and suicidal behaviour: results from a 25-year longitudinal study
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DOI：
10.1017/s0033291707001547
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发表时间：
2008-03-01
影响因子：
6.9
通讯作者：
Horwood, L. J.
中科院分区：
文献类型：
--
作者：
Boden, J. M.;Fergusson, D. M.;Horwood, L. J.
背景本研究采用固定效应回归模型，在控制潜在混杂因素之前和之后，检验吸烟与自杀意念和自杀企图之间的关联。数据是在基督城健康和发展研究期间收集的，这是一项对新西兰儿童（635名男性，630名女性）出生队列进行的25年纵向研究。该分析基于1041名参与者的样本，这些参与者具有16至25岁吸烟和自杀行为的可用数据。主要观察指标为自杀意念和自杀未遂，年龄分别为16- 18岁，18 -21岁和21- 25岁。吸烟频率与自杀想法和自杀企图之间存在显着的双变量关联。每天吸烟20支或更多的队列成员的自杀意念的几率是非吸烟者的3.39倍（95%CI 2.06-5.59），自杀企图的几率是非吸烟者的4.39倍（95%CI 2.18-8.85）。对未观察到的固定混杂因素进行控制后，吸烟与自杀意念和自杀企图之间的相关性降低至无统计学意义。经校正后，每日吸烟20支以上者自杀意念发生率是不吸烟者的1.00倍（95%CI 0.46-2.18），自杀未遂发生率是不吸烟者的1.84倍（95%CI 0.81-4.18）。研究结果表明，吸烟频率和自杀行为之间的关联可能在很大程度上可以通过与吸烟和自杀行为相关的未观察到的背景因素和生活环境来解释。
Background. This study examined the associations between cigarette smoking and suicidal ideation and suicide attempts, both before and after control for potentially confounding using fixed effects regression models.Method. Data were gathered during the Christchurch Health and Development Study, a 25-year longitudinal study of a birth cohort of New Zealand children (635 males, 630 females). The analysis was based on a sample of 1041 participants with available data on cigarette smoking and suicidal behaviour from ages 16 to 25 years. The main outcome measures were suicidal ideation and suicide attempts, ages 16-18,18-21, and 21-25.Results. There were significant bivariate associations between the frequency of cigarette smoking and both suicidal ideation and suicide attempts. Cohort members who smoked 20 or more cigarettes per day had odds of suicidal ideation that were 3.39 times (95% CI 2.06-5.59) those of non-smokers, and odds of suicide attempt that were 4.39 (95% CI 2.18-8.85) times those of non-smokers. Control for non-observed fixed confounding factors reduced the association between cigarette smoking and suicidal ideation and suicide attempts to statistical non-significance. After adjustment, those smoking more than 20 cigarettes per day had odds of suicidal ideation that were 1.00 times (95% CI 0.46-2.18) those of non-smokers, and odds of suicide attempt that were 1.84 (95% CI 0.81-4.18) times those of nonsmokers.Conclusions. The findings suggest that the associations between frequency of cigarette smoking and suicidal behaviour may largely be explained by the non-observed background factors and life circumstances that are associated with both cigarette smoking and suicidal behaviour.