Increased Levels of C1q in the Prefrontal Cortex of Adult Offspring after Maternal Immune Activation: Prevention by 7,8-Dihydroxyflavone.
Increased Levels of C1q in the Prefrontal Cortex of Adult Offspring after Maternal Immune Activation: Prevention by 7,8-Dihydroxyflavone.
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DOI：
10.9758/cpn.2017.15.1.64
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发表时间：
2017-02-28
期刊：
影响因子：
--
通讯作者：
Hashimoto K
中科院分区：
文献类型：
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作者：
Han M;Zhang JC;Hashimoto K
产前感染与精神分裂症的病因有关。本研究旨在探讨补体蛋白C1q在母体免疫激活(MIA)后成年子代精神障碍中的作用。此外，还观察了7，8-二羟基黄酮(7，8-DHF：原肌球蛋白受体激酶B激动剂)的作用。用免疫印迹法检测胎龄12~17岁的成年仔鼠暴露于Poly(I：C)(5.0 mg/kg/d)后脑区C1q的表达。7，8-DHF或赋形剂在4~8周龄给药。经Poly(I：C)处理的妊娠小鼠成年子代前额叶皮质(PFC)中C1q的表达显著高于对照组。少年和青春期早期应用7，8-DHF可预防MIA后成年子代PFC中C1q的增加。因此，C1q在额叶皮质的表达增加可能在MIA后成年子代行为异常中起一定作用。此外，在MIA前驱期补充TrkB激动剂如7，8-DHF可能对MIA后的行为异常有预防作用。
Prenatal infection is implicated in the etiology of schizophrenia. The objective of this paper is to study the role of complement protein C1q in the psychosis of adult offspring after maternal immune activation (MIA). In addition, effect of 7,8-dihydroxyflavone (7,8-DHF: a tropomyosin receptor kinase B [TrkB] agonist) was also examined. Western blot analysis of C1q in the brain regions from adult offspring after prenatal poly(I:C) (5.0 mg/kg/day from E12 to E17) exposure was performed. 7,8-DHF or vehicle was given from 4 to 8-weeks old. Expression of C1q in the prefrontal cortex (PFC) of adult offspring from poly(I:C)-treated pregnant mice was significantly higher than that of control group. Early treatment with 7,8-DHF during juvenile and adolescent stages could prevent an increase of C1q in the PFC of adult offspring after MIA. Therefore, it is likely that increased C1q expression in the frontal cortex may play a role in the behavioral abnormalities of adult offspring after MIA. Furthermore, supplementation with a TrkB agonist such as 7,8-DHF during the prodromal stage may have prophylactic effects on the behavioral abnormalities after MIA.