D-cycloserine: Effects on long-term retention of a conditioned response and on memory for contextual attributes
D-cycloserine: Effects on long-term retention of a conditioned response and on memory for contextual attributes
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DOI：
10.1006/nlme.1998.3897
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发表时间：
1999-11-01
影响因子：
2.7
通讯作者：
Riccio, DC
中科院分区：
文献类型：
--
作者：
Land, C;Riccio, DC
D-环丝氨酸（DCS），甘氨酸的部分激动剂！N-甲基D-天冬氨酸受体的识别位点，对学习和记忆具有有益的作用。为了研究其影响学习和记忆的潜力的反应和刺激属性的训练，雄性Sprague-Dawley白化病大鼠在一个试验抑制回避任务后，急性腹腔注射DCS（3 mg/kg）或等体积的生理盐水。为了测量刺激属性的记忆，测试涉及上下文转换范式，其中受试者在训练环境或不同的环境中进行测试。对训练的上下文属性的良好记忆由在替代上下文中的较差表现指示。在训练后1、7或14天评估保留。在第1天，生理盐水组受试者受到环境变化的影响，而DCS组受试者则没有。在训练后1周测试的受试者中，生理盐水受试者不再受环境变化的影响，因为他们在两种环境中都进行了回避反应。这表明生理盐水受试者忘记了刺激属性。DCS受试者在第1周时确实表现出情境转移效应，表明刺激属性的保留。最后，生理盐水受试者在14天时表现出背景转换反弹，而DCS受试者在两种情况下表现相当。总之，这些数据表明，DCS可能会增强恐惧的保留，减缓对刺激属性的遗忘。(C)北京：科学出版社.
D-Cycloserine (DCS), a partial agonist of the glycine! recognition site of the N-methyl D-aspartate receptor, has beneficial effects on learning and memory. In order to investigate its potential to influence learning and memory of both the response and the stimulus attributes of training, male Sprague-Dawley albino rats were trained in a one-trial inhibitory avoidance task following an acute intraperitoneal injection of DCS (3 mg/kg) or an equal volume of saline. In order to-measure memory for stimulus attributes, testing involved a context shift paradigm, in which subjects are tested in either the environment of training or a different one. Good memory for the contextual attributes of training is indicated by poor performance in the alternate context. Retention was assessed either 1, 7, or 14 days after training. At 1 day, Saline subjects were affected by a change in context, while DCS subjects were not. In subjects tested 1 week following training, Saline subjects were no longer affected by a change in context, in that they performed the avoidance response in both contexts. This indicates the forgetting of stimulus attributes in Saline subjects. DCS subjects did show the context shift, effect at I week, indicating the retention of stimulus attributes. Finally, Saline subjects demonstrated the context shift rebound at 14 days, while DCS subjects performed equivalently in both contexts. Taken together, these data suggest that DCS may enhance retention of fear and slow the forgetting Of stimulus attributes. (C) 1999 Academic Press.