Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1.
Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1.
复制标题
反式显性基因座 Tse-1 对编码糖异生酶的两个基因进行协调调节。
DOI：
10.1073/pnas.85.19.7302
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发表时间：
1988
影响因子：
11.1
通讯作者：
Fournier,RE
中科院分区：
文献类型：
--
作者：
Lem,J;Chin,AC;Thayer,MJ;Leach,RJ;Fournier,RE
Tissue-specific extinguisher-1 (Tse-1) is a mouse genetic locus that can repress liver-specific tyrosine aminotransferase gene expression in trans. To search for other Tse-1-responsive genes, hepatoma microcell hybrids retaining mouse chromosome 11 or human chromosome 17, containing murine Tse-1 and human TSE1, respectively, were screened for expression of liver-specific mRNAs. While most liver gene activity was unaffected in such hybrids, phosphoenolpyruvate carboxykinase and tyrosine aminotransferase gene expression was coordinately repressed in these clones. Extinction of both genes was apparently mediated by a single genetic locus that resides on human chromosome 17.
