The effects of the ionophore A-23187 on the rat vas deferens.
The effects of the ionophore A-23187 on the rat vas deferens.
复制标题
离子载体 A-23187 对大鼠输精管的影响。
DOI：
10.1139/y83-012
复制
发表时间：
1983
影响因子：
2.1
通讯作者：
M. Vohra
中科院分区：
文献类型：
--
作者：
M. W. Warenycia;M. Vohra
钙离子载体A-23187在大鼠离体输精管中以浓度依赖性方式诱导自发的节律性收缩。酚妥拉明阻断收缩，利血平预处理后收缩消失。在预载[3 H]去甲肾上腺素的组织中，A-23187（10 μ M）引起氚释放的时间依赖性增加。结果表明，A-23187诱导的大鼠输精管收缩继发于肾上腺素能神经释放内源性去甲肾上腺素，其他研究者先前描述的X-537 A（另一种钙离子载体）诱导的该制剂收缩也是如此。
The calcium ionophore A-23187 induced spontaneous, rhythmic contractions in the rat isolated vas deferens in a concentration-dependent manner. Contractions were blocked by phentolamine and were abolished following pretreatment with reserpine. In tissues preloaded with [3H]noradrenaline, A-23187 (10 microM) caused a time-dependent increase in the release of tritium. The findings suggest that A-23187-induced contractions in the rat vas deferens are secondary to the release of endogenous noradrenaline from the adrenergic nerves, as are contractions induced in this preparation by X-537A (another calcium ionophore) described earlier by other investigators.