The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs
The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs
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DOI：
10.1038/sj.mp.4001084
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发表时间：
2002-01-01
影响因子：
11
通讯作者：
Licinio, J
中科院分区：
文献类型：
--
作者：
Kim, YK;Suh, IB;Licinio, J
白细胞介素-12（IL-12）在促进辅助性T细胞1（Th 1）应答和随后的细胞介导的免疫中起关键作用。考虑到细胞因子在精神疾病发病机制中的作用，IL-12在这些疾病中的失调是可以预期的。我们检测了102例精神病患者（43例精神分裂症，34例抑郁症和25例双相情感障碍）和85名正常对照者的血浆IL-12水平。此外，在8周治疗后测量患者的IL-12水平，以评估水平是否受到药物的影响。抑郁症患者组IL-12水平显著高于对照组，而其他各组间无显著性差异。治疗8周后，三个患者组的IL-12值显著降低。这些研究结果支持的假设，炎症反应系统，特别是Th-1样细胞的激活，参与了重性抑郁症的病理生理学和反复给药的抗抑郁和抗精神病药物可能会抑制IL-12的血浆浓度在精神病患者。
Interleukin-12 (IL-12) plays a key role in promoting T helper 1 (Th1) responses and subsequent cell-mediated immunity. Given the role of cytokines in the pathogenesis of psychiatric disorders, the dysregulation of IL-12 in these illnesses would be expected. We measured the plasma levels of IL-12 in 102 psychiatric patients (43 schizophrenia, 34 major depression and 25 bipolar disorder) and 85 normal controls. In addition, IL-12 levels of the patients were measured after an 8-week treatment to assess whether the levels were affected by medication. The IL-12 levels of the patient group with major depression were significantly higher than that of the control group, whereas no differences were found among the other groups. IL-12 values of the three patient groups decreased significantly after 8 weeks of treatment. These findings support the hypothesis that activation of the inflammatory response system and in particular of Th-1-like cells, is involved in the pathophysiology of major depression and that repeated administration of antidepressive and antipsychotic drugs may suppress IL-12 plasma concentrations in psychiatric patients.