A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
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DOI：
10.1038/36593
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发表时间：
1997-11-13
期刊：
影响因子：
64.8
通讯作者：
Galibert, L
中科院分区：
文献类型：
--
作者：
Anderson, DM;Maraskovsky, E;Galibert, L
树突状细胞是存在于许多器官和组织中的稀有造血细胞。通过捕获、处理抗原并将其呈递给 T 细胞，树突细胞对于免疫监视和特异性免疫调节至关重要(1-4) 肿瘤坏死因子受体 (TNFR) 超家族的多个成员对于免疫反应的调节至关重要。这些结构相关的蛋白质调节从增殖和分化到炎症和细胞存活或死亡的细胞功能(5,6)。树突状细胞的功能活性通过 TNFR 家族成员 CD40 的信号大大增强（参考文献 7、8）。在这里，我们报告了 RANK（NF-κ B 受体激活剂）的表征，RANK 是源自树突状细胞的 TNFR 家族的新成员，以及通过直接表达筛选分离 RANK 配体 (RANKL)。 RANKL 增强了树突状细胞在混合淋巴细胞反应中刺激初始 T 细胞增殖的能力，并提高了用白细胞介素 4 和转化生长因子 (TGF)-β 生成的 RANK(+) T 细胞的存活率。因此，RANK 和 RANKL 似乎是 T 细胞和树突状细胞之间相互作用的重要调节因子。
Dendritic cells are rare haematopoietic cells that reside in a number of organs and tissues. By capturing, processing and presenting antigens to T cells, dendritic cells are essential for immune surveillance and the regulation of specific immunity(1-4) Several members of the tumour necrosis factor receptor (TNFR) superfamily are integral to the regulation of the immune response. These structurally related proteins modulate cellular functions ranging from proliferation and differentiation to inflammation and cell survival or death(5,6). The functional activity of dendritic cells is greatly increased by signalling through the TNFR family member CD40 (refs 7, 8). Here we report the characterization of RANK (for receptor activator of NF-kappa B), a new member of the TNFR family derived from dendritic cells, and the isolation of a RANK ligand (RANKL) by direct expression screening. RANKL augments the ability of dendritic cells to stimulate naive T-cell proliferation in a mixed lymphocyte reaction, and increases the survival of RANK(+) T cells generated with interleukin-4 and transforming growth factor (TGF)-beta. Thus RANK and RANKL seem to be important regulators of interactions between T cells and dendritic cells.