Pathophysiology and treatment options for gastroesophageal reflux disease: looking beyond acid.
Pathophysiology and treatment options for gastroesophageal reflux disease: looking beyond acid.
复制标题
胃食管反流疾病的病理生理和治疗选择：酸远。
DOI：
10.1111/nyas.14501
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发表时间：
2021-03
影响因子：
5.2
通讯作者：
Yadlapati, Rena
中科院分区：
文献类型：
--
作者：
Sharma, Priya;Yadlapati, Rena
关键词：
胃食道反流病(GERD)是一种由于反流物逆流进入食道而引起的疾病。虽然GERD是一种常见的临床诊断，但其发病机制相当复杂。作为其多因素发展的结果，尽管质子泵抑制剂治疗延长了酸抑制时间，许多患者仍因GERD而出现不良症状。GERD的发病机制涉及化学、机械、心理和神经机制的相互作用，这些机制有助于症状的呈现、诊断和治疗。因此，GERD应该被视为一种超越酸的障碍。本文将探讨GERD发生发展的主要因素，包括与反流有关的因素、食道防御以及促进病理性反流进入食道的因素。在回顾GERD的发病机制时，本文将重点介绍GERD的治疗进展，并提及未来探讨GERD的研究机会。
Gastroesophageal reflux disease (GERD) is a disorder due to the retrograde flow of refluxate into the esophagus. Although GERD is a common clinical diagnosis, its pathogenesis is quite complex. As a result of its multifactorial development, many patients continue to experience adverse symptoms due to GERD despite prolonged acid suppression with proton pump inhibitor therapy. The pathogenesis of GERD involves an interplay of chemical, mechanical, psychologic, and neurologic mechanisms, which contribute to symptom presentation, diagnosis, and treatment. As such, GERD should be approached as a disorder beyond acid. This review will investigate the major factors that contribute to the development of GERD, including factors related to the refluxate, esophageal defenses, and factors that promote pathologic reflux into the esophagus. In reviewing GERD pathogenesis, this paper will highlight therapeutic advances, with mention of future opportunities of study when approaching GERD.
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影响因子：
7.6
作者：
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通讯作者：
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