Household Income, Cortisol, and Obesity During Early Childhood: A Prospective Longitudinal Study.
Household Income, Cortisol, and Obesity During Early Childhood: A Prospective Longitudinal Study.
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儿童早期的家庭收入、皮质醇和肥胖：一项前瞻性纵向研究。
DOI：
10.1016/j.jpeds.2022.09.007
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
French,SimoneA
中科院分区：
文献类型：
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作者：
Kunin-Batson,AliciaS;Crain,ALauren;Gunnar,MeganR;Kelly,AaronS;Kharbanda,ElyseO;Haapala,Jacob;Seburg,ElisabethM;Sherwood,NancyE;French,SimoneA
目的前瞻性评估家庭收入、儿童皮质醇水平与儿童3年内体重指数（BMI）变化轨迹之间的关系。研究设计家庭收入、儿童头发皮质醇水平和BMI在基线、12个月、2 - 4个月和36个月的随访中在Now Everybody Together for Amazing and Healthy Kids（NET-Works）研究中测量（n= 534，2-4岁儿童，基线时家庭收入<65000美元/年）。使用调整后的线性生长曲线模型，研究了基线时极低家庭收入（<25000美元/年）、随时间推移的收入状况（保持<25000美元/年或收入增加）、头发样本中皮质醇积累和BMI第95百分位数百分比（BMIp 95）轨迹之间的关系。基线收入在25 000美元和65 000美元/年之间的家庭是所有分析的参考组。结果基线时来自极低收入家庭的儿童BMIp 95的年度变化较高（P<. 001)与参照组家庭的儿童相比（0.40 vs-0.62百分比单位/年）。来自低收入家庭的儿童BMIp 95的年增长率也更高（P<0.05）。01,. 34%单位/年）和收入增加的人（P=. 01,. 51%单位/年）与参考组（-0.61%单位/年）相比。来自收入仍然很低的家庭的儿童有较高的头发皮质醇积累（0.22 pg/mg，P=. 02)而来自收入增加家庭的儿童的头发皮质醇浓度（0.03 pg/mg）与参考组没有显著差异。皮质醇与BMIp 95无关。结论家庭的经济状况可能会影响儿童的BMI轨迹和他们的发展压力系统，但这些过程可能是相互独立的。
Objective To prospectively evaluate the relationship between household income, children's cortisol, and body mass index (BMI) trajectories over a 3-year period in early childhood. Study design Household income, child hair cortisol levels, and BMI were measured at baseline, 12-, 24-, and 36-month follow-up visits in the Now Everybody Together for Amazing and Healthful Kids (NET-Works) Study (n= 534, children ages 2-4 years, and household income< $65 000/year at baseline). Relationships were examined between very low household income (< $25 000/year) at baseline, income status over time (remained< $25 000/year or had increasing income), cortisol accumulation from hair samples, and BMI percent of the 95th percentile (BMIp95) trajectories using adjusted linear growth curve modeling. Households with baseline income between $25 000 and $65 000/year were the reference group for all analyses. Results Children from very low-income households at baseline had annual changes in BMIp95 that were higher (P<. 001) than children from reference group households (0.40 vs− 0.62 percentage units/year). Annual increases in BMIp95 were also greater among children from households that remained very low income (P<. 01,. 34 percentage units/year) and among those with increasing income (P=. 01,. 51 percentage units/year) compared with the reference group (− 0.61 percentage units/year). Children from households that remained very low income had higher hair cortisol accumulations (0.22 pg/mg, P=. 02) than reference group children, whereas hair cortisol concentrations of children from households with increasing income (0.03 pg/mg) did not differ significantly from the reference group. Cortisol was not related to BMIp95. Conclusions The economic circumstances of families may impact children's BMI trajectories and their developing stress systems, but these processes may be independent of one another.