Rhodium-Catalyzed Selective C-H Activation/Olefination of Phenol Carbamates
Rhodium-Catalyzed Selective C-H Activation/Olefination of Phenol Carbamates
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铑催化苯酚氨基甲酸酯的选择性 C-H 活化/烯化反应
DOI：
10.1021/ol201140q
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发表时间：
2011-06-17
期刊：
影响因子：
5.2
通讯作者：
Liu, Lei
中科院分区：
文献类型：
--
作者：
Gong, Tian-Jun;Xiao, Bin;Liu, Lei
研究了Rh（III）催化的邻位C-H活化/烯化反应。观察到高区域选择性与一系列的苯酚氨基甲酸酯，使有效的偶联与丙烯酸酯和苯乙烯。该反应与钯催化苯酚酯的邻位芳基化反应相比具有不同的反应活性，为邻位取代苯酚的合成提供了一条新的途径。
Rh(III)-catalyzed ortho C-H activation/olefination of phenol carbamates has been developed. High regioselectivity is observed with a range of phenol carbamates enabling efficient coupling with acrylates and styrenes. This reaction exhibits different reactivity as compared to the Pd-catalyzed ortho-arylation reaction of phenol esters and provides a new approach for the synthesis of ortho-substituted phenols.