Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units
Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units
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DOI：
10.1086/429634
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发表时间：
2005-05-01
影响因子：
6.4
通讯作者：
Plummer, F
中科院分区：
文献类型：
--
作者：
Booth, TF;Kournikakis, B;Plummer, F
严重急性呼吸系统综合征（SARS）的特点是医院传播的风险;然而，空气传播SARS的风险是未知的。在多伦多SARS爆发期间，我们采用新颖的空气采样和传统的表面擦拭，调查了SARS单位的环境污染。从一名SARS患者居住的房间中采集了两个聚合酶链反应（PCR）阳性的空气样本，表明该房间的空气中存在病毒。此外，从SARS患者居住的房间（床桌和电视遥控器）和工作人员使用的护士站（药物冰箱门）中经常接触的表面回收了几个PCR阳性拭子样本。这些数据首次通过实验证实了SARS患者产生病毒气溶胶的可能性，表明空气飞沫传播的可能性，这强调了需要充分的呼吸保护以及严格的表面卫生习惯。
Severe acute respiratory syndrome (SARS) is characterized by a risk of nosocomial transmission; however, the risk of airborne transmission of SARS is unknown. During the Toronto outbreaks of SARS, we investigated environmental contamination in SARS units, by employing novel air sampling and conventional surface swabbing. Two polymerase chain reaction (PCR)-positive air samples were obtained from a room occupied by a patient with SARS, indicating the presence of the virus in the air of the room. In addition, several PCR-positive swab samples were recovered from frequently touched surfaces in rooms occupied by patients with SARS (a bed table and a television remote control) and in a nurses' station used by staff (a medication refrigerator door). These data provide the first experimental confirmation of viral aerosol generation by a patient with SARS, indicating the possibility of airborne droplet transmission, which emphasizes the need for adequate respiratory protection, as well as for strict surface hygiene practices.