Water-soluble soft nano-colloid for drug delivery
Water-soluble soft nano-colloid for drug delivery
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用于药物输送的水溶性软纳米胶体
DOI：
10.1016/j.matlet.2009.05.010
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发表时间：
2009-08-15
影响因子：
3
通讯作者：
Liu, Ji Hua
中科院分区：
文献类型：
--
作者：
Zhou, Lin;Dong, Chao;Liu, Ji Hua
光动力疗法（PDT）已被证明在治疗不同类型的癌症方面是非常有效的。疏水性光敏剂elsinochrome A (EA) PDT的新型纳米胶体药物载体。采用单3-氨基丙基三乙氧基硅烷（APTES）制备，传统上APTES仅用作表面改性剂。所得纳米胶体固定化光敏剂具有良好的水溶性和光稳定性。此外，EANC还保留了光动力作用所必需的单重态氧光生成的关键步骤。此外，光照射对小牛胸腺DNA有明显的损伤。因此，利用纳米胶体作为光动力治疗药物载体的潜力已经被证明。(C) 2009 Elsevier B.V.版权所有
Photodynamic therapy (PDT) has been proved to be highly effective in the treatment of different types of cancer. A novel nano-colloid based drug carrier for PDT of elsinochrome A (EA), a hydrophobic photosensitizer. was prepared using single 3-aminopropyltriethoxysilane (APTES) which is traditionally only used as surface modification reagent. The resulting nano-colloid immobilized photosensitizers provide good water solubility and photostability. In addition, EANC preserve the key step of photogeneration of singlet oxygen, necessary for photodynamic action. Moreover, significant damage to calf thymus DNA was observed upon irradiation with light. Thus, the potential of using nano-colloid as drug carriers for photodynamic therapy has been demonstrated. (C) 2009 Elsevier B.V. All rights reserved.