The cholinergic anti-inflammatory pathway: an innovative treatment strategy for respiratory diseases and their comorbidities
The cholinergic anti-inflammatory pathway: an innovative treatment strategy for respiratory diseases and their comorbidities
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DOI：
10.1016/j.coph.2017.12.003
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发表时间：
2018-06-01
影响因子：
4
通讯作者：
Ichinose, Masakazu
中科院分区：
文献类型：
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作者：
Yamada, Mitsuhiro;Ichinose, Masakazu
在过去的几十年中，已经阐明神经系统和免疫系统具有重叠的分布，并且它们的相互作用在免疫和炎症反应的调节中是至关重要的。胆碱能抗炎通路，包括副交感神经系统和体液因子协调免疫反应，以在感染和组织损伤期间保护身体。最近的研究试图阐明副交感神经系统如何减弱全身炎症反应，并确定α 7烟碱乙酰胆碱受体（α 7 nAChR）作为减弱炎症细胞（包括巨噬细胞和树突状细胞）释放炎性细胞因子的关键靶标。这条调节回路可能存在于肺部，并可能参与调节感染和其他炎症性肺部疾病（包括哮喘和COPD）期间的炎症和免疫，这意味着胆碱能抗炎通路的调节可能是肺部疾病的治疗靶点。
Over the past few decades, it has been clarified that the nervous system and immune system have overlapping distributions and their interactions are critical in the regulation of immunological and inflammatory responses. The cholinergic anti-inflammatory pathway, including the parasympathetic nerve systems and humoral factors orchestrate the immune responses to protect the body during infection and tissue injury. Recent investigations have attempted to clarify how the parasympathetic nerve systems attenuate the systemic inflammatory responses and identified the alpha 7 nicotinic acetylcholine receptor (alpha 7nAChR) as a crucial target for attenuating the release of inflammatory cytokines from inflammatory cells including macrophages and dendritic cells. This modulatory circuit pathway possibly exists in the lungs and might be involved in regulating inflammation and immunity during infection and other inflammatory lung diseases including asthma and COPD, which means that modulation of the cholinergic anti-inflammatory pathway is a possible therapeutic target for lung diseases.