A MATHEMATICAL-MODEL OF THE DEVELOPMENT OF DRUG-RESISTANCE TO CANCER-CHEMOTHERAPY
A MATHEMATICAL-MODEL OF THE DEVELOPMENT OF DRUG-RESISTANCE TO CANCER-CHEMOTHERAPY
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DOI：
10.1016/0277-5379(87)90133-7
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发表时间：
1987-09-01
期刊：
影响因子：
--
通讯作者：
RUBENS, RD
中科院分区：
文献类型：
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作者：
BIRKHEAD, BG;RANKIN, EM;RUBENS, RD
结合肿瘤生长动力学和细胞毒化疗对已建立的肿瘤的影响的描述的数学模型。它示出了如何使用这种模型来调查潜在的假设化疗策略，并确定成功治疗的一般原则。该模型旨在帮助临床医生为进展令人失望的疾病设计新的化疗方案。
A mathematical model incorporating descriptions of tumour growth kinetics and the effects of cytotoxic chemotherapy on established tumours, is presented. It is shown how models of this kind may be used to investigate the potential of hypothetical chemotherapy strategies, and to identify general principles for successful treatment. The model is intended to be an aid to clinicians designing new chemotherapy programs for diseases in which progress has been disappointing.